Words similar to src
Example sentences for: src
How can you use “src” in a sentence? Here are some example sentences to help you improve your vocabulary:
However, we found that placing the Cas SD at the N-terminus of the Src kinase domain was inferior to placing it at the C-terminus with regards to tyrosine phosphorylation of the Cas SD.
Upon such fractionation, we observe the Src family kinase Fyn constitutively associated with the RAFT fraction (Fig.
The adaptor protein Cas has several domains that are important for its function, an SH3 domain, a central substrate domain with up to 15 tyrosines that can serve as tyrosine kinase substrates for upstream kinases such as Src and Abl [ 19 42 43 ] , and a C-terminal Src binding domain with PXXP motifs for binding to the SH3 domain of Src, and two tyrosines providing docking sites for the Src SH2 domain upon phosphorylation [ 6 ] . The substrate domain of Cas has two major types of tyrosine motifs that can be phosphorylated and bind downstream effectors, YQXP (4 copies) and YDXP motifs (9 copies), suggesting that at least two classes of downstream effectors, one capable of binding to YDXP motifs and the other capable of binding to YQXP motifs, are assembled by this adaptor protein.
Like other proteins modified by palmitoylation, the Src family kinase Fyn is found localized in RAFTs, a membrane microdomain fraction enriched in signaling molecules that can be isolated by sucrose gradient fractionation.
Initially, we expressed the Src KM/Cas(SD) (entire Cas SD) in Cos-7 cells alone, or along with wild type (WT) v-crk, or v-crk SH2 or SH3 mutants and assayed for tyrosine phosphorylation and association by co-immunoprecipitation (Fig.
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