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Example sentences for: src-
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The nuclear receptor (NR) family comprises 48 structurally related transcription factors, many of which require their cognate ligand for activity [ 1 2 3 ] . The NRs regulate transcription by binding to response elements in the promoters of target genes and acting as scaffolds for the assembly of large coactivator and corepressor complexes [ 4 ] . NR coactivators include the p160s (including GRIP1/TIF-2, SRC-1 and AIB1/ACTR/pCIP).
The NcoA family members constitute SRC-1/NcoA-1 [ 89 ] , TIF2/GRIP1/NcoA-2, [ 94 95 ] and pCIP/ACTR/AIB1 [ 96 97 98 ] proteins, which interact with liganded RA receptor (RAR), and CBP/p300.
Cumulatively, however, these observations do suggest a mechanism whereby HIV-1 expression in renal epithelium may induce cyclin D 1 : activation of Src-family kinases by Nef would be expected to up-regulate cyclin D 1 gene expression and promote the synthesis and stabilization of cyclin D 1 protein via Src-Ras-MAPK and Src-PI3K-mTOR signal transduction pathways, respectively [ 32 33 34 ] . Interestingly, our unpublished in vitro observations and published data showing marked expression of basic fibroblast growth factor in the interstitium of HIVAN kidneys [ 35 ] suggest that soluble mitogens may be important cofactors with HIV-1 expression to induce cyclin D 1 . Thus, interrupting HIV-1 gene expression should down-regulate cyclin D 1 and correct the phenotypic abnormalities in infected podocytes.
CV-1 cells were transfected with the same amount (2 μg) of plasmid expressing Stat3C, SRC-1, CBP/p300, TIF-2 or P/CAF, respectively.
Moreover, Stat3 has also been directly associated with several coactivators, such as SRC-1 and CBP/p300 [ 9 12 ] . Recruitment of coactivators to nuclear receptors takes place via a common motif in the coactivators containing a core consensus sequence LXXLL (L, leucine; X, any aminoacid) [ 38 ] . Most of the coactivators contain more than one of these motifs, raising the question regarding specificity of these motifs to specific activating domains in the nuclear receptors.
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