Words similar to src-
Example sentences for: src-
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CV-1 cells were transfected with the same amount (2 μg) of plasmid expressing Stat3C, SRC-1, CBP/p300, TIF-2 or P/CAF, respectively.
Other NR coactivators include TRAP220 [ 7 ] , which is part of a larger complex (TRAP/DRIP/SMCC/mediator) that contacts the basal transcription machinery and PGC-1 [ 8 ] , a cold inducible coactivator that binds CBP and SRC-1 and proteins involved in RNA processing [ 9 ] . NR corepressors include NR corepressor (N-CoR) and silencing mediator of retinoid and thyroid responsive transcription (SMRT) [ 4 ] . Both N-CoR and SMRT repress transcription, at least in part, by binding to histone de-acetylases (HDACs) either directly or indirectly through other corepressor complex components.
The down-regulation is most apparent on cellular receptors that have intrinsic receptor tyrosine kinase (RTK) activity and signal transduction members that mediate RTK function; including the Ras-Raf-MEK pathway, and co-activators such as p300/CBP and SRC-1, which mediate gene expression related to hormone receptor genes.
Moreover, Stat3 has also been directly associated with several coactivators, such as SRC-1 and CBP/p300 [ 9 12 ] . Recruitment of coactivators to nuclear receptors takes place via a common motif in the coactivators containing a core consensus sequence LXXLL (L, leucine; X, any aminoacid) [ 38 ] . Most of the coactivators contain more than one of these motifs, raising the question regarding specificity of these motifs to specific activating domains in the nuclear receptors.
In addition, SRC-3 binding to the heterodimer was decreased by androstanol and this effect was largely blocked by 9-cis-RA.
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