Words similar to src-
Example sentences for: src-
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To test the effects of rexinoids on coactivator binding in a defined biochemical system, surface plasmon resonance was used to characterize the effects of the various ligands on binding of CAR, RXR and CAR/RXR heterodimers to SRC-3 (also known as ACTR, p/CIP, RAC3, AIB1, TRAM-1), an effective coactivator for CAR and many other members of the nuclear receptor superfamily.
In addition, SRC-3 binding to the heterodimer was decreased by androstanol and this effect was largely blocked by 9-cis-RA.
Cumulatively, however, these observations do suggest a mechanism whereby HIV-1 expression in renal epithelium may induce cyclin D 1 : activation of Src-family kinases by Nef would be expected to up-regulate cyclin D 1 gene expression and promote the synthesis and stabilization of cyclin D 1 protein via Src-Ras-MAPK and Src-PI3K-mTOR signal transduction pathways, respectively [ 32 33 34 ] . Interestingly, our unpublished in vitro observations and published data showing marked expression of basic fibroblast growth factor in the interstitium of HIVAN kidneys [ 35 ] suggest that soluble mitogens may be important cofactors with HIV-1 expression to induce cyclin D 1 . Thus, interrupting HIV-1 gene expression should down-regulate cyclin D 1 and correct the phenotypic abnormalities in infected podocytes.
[ 18 ] . This constitutively activated Stat3 (a mutant produced by substitution of the cysteine residues within the COOH-terminal loop of the SH2 domain of Stat3) induces cellular transformation and tumor formation in nude mice [ 18 ] . The plasmids to express other coactivators (SRC-1, CBP/p300, TIF2 and PCAF) have been described elsewhere [ 29 30 ] .
The nuclear receptor (NR) family comprises 48 structurally related transcription factors, many of which require their cognate ligand for activity [ 1 2 3 ] . The NRs regulate transcription by binding to response elements in the promoters of target genes and acting as scaffolds for the assembly of large coactivator and corepressor complexes [ 4 ] . NR coactivators include the p160s (including GRIP1/TIF-2, SRC-1 and AIB1/ACTR/pCIP).
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