Words similar to src-

Example sentences for: src-

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The nuclear receptor (NR) family comprises 48 structurally related transcription factors, many of which require their cognate ligand for activity [ 1 2 3 ] . The NRs regulate transcription by binding to response elements in the promoters of target genes and acting as scaffolds for the assembly of large coactivator and corepressor complexes [ 4 ] . NR coactivators include the p160s (including GRIP1/TIF-2, SRC-1 and AIB1/ACTR/pCIP).
Recently, overexpression of SRC-1 and TIF-2 has been found in prostate cancer recurrence after androgen deprivation therapy [ 44 ] , providing a molecular basis for AR activation that could be similar to the one displayed by Stat3 in its role as coactivator.
As expected, 9-cis-RA stimulated coactivator binding to RXR alone, and the basal interaction of CAR with SRC-3 was enhanced by TCPOBOP and decreased by androstanol (Fig.
Stat3 is comparable to other coactivators on AR transcriptional activity: SRC-1, CBP/p300, TIF2, P/CAF.
In addition, SRC-3 binding to the heterodimer was decreased by androstanol and this effect was largely blocked by 9-cis-RA.