Example sentences for: sequence-structure

How can you use “sequence-structure” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To gain a better understanding of the functions and evolution of these regulatory proteins, we initiated a detailed analysis of their sequences using position-specific-score matrix searches, sequence-structure threading, secondary-structure prediction and structure comparisons.

  • Furthermore, methods based on a different principle, such as protein sequence-structure threading, have a recent history of success despite uncertainties in their statistical foundations [ 22, 53, 54, 55, 56].

  • The sequence-structure threading with the 3D-PSSM method recovered the APSES domain structure (PDB 1bm8/1bm1) as the best hit for the Bro-N domain, albeit with statistically insignificant E-values.

  • However, neither direct comparisons, nor sequence-structure threading revealed any relationship with the two other well-characterized α-helical heme-binding domains, namely globin and cytochrome C. Hence, it is likely that the HNOB domain adopts a structure distinct from these domains.

  • Such studies typically require a case-by-case approach that is guided by a detailed understanding of protein sequence-structure patterns and is rooted in the biology of the proteins analyzed.


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