Example sentences for: sequence-specific

How can you use “sequence-specific” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Finally, non-peptidic molecules that bind in a sequence-specific manner to DNA have been fused to 20- and 16-residue peptides.

  • Similarly, TOX is more closely aligned with the sequence-independent HMG-box proteins than the sequence-specific transcription factors at position 65.

  • Human SRY, murine SOX-4, SOX-17, and LEF-1 contain single HMG-box motifs and bind DNA in a sequence-specific fashion.

  • Runx genes encode the sequence-specific DNA binding subunit of a heterodimeric transcription factor, the defining feature of which is the Runt domain, a highly conserved 128 amino acid sequence involved in DNA binding, heterodimerization, nucleotide binding, and nuclear localization [ 1 2 ] . The Runt domain is named after the first member of the family to be discovered, the regulatory gene runt from Drosophila melanogaster . Runx genes have also been discovered and functionally characterized in mammals, sea urchins and nematodes, and in general are involved in the transcriptional control of developmental processes [ 3 4 ] . In humans, mutations in each of the three Runx genes are associated with disease caused by defective control of cell proliferation and/or differentiation [ 4 5 ] . Most studies of Runx gene function and regulation have been carried out in mammals and in D. melanogaster , each of which has multiple Runx genes.

  • The second group of HMG-box proteins recognizes DNA in a sequence-specific manner akin to more traditional transcription factors.


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