Words similar to sequence-specific
Example sentences for: sequence-specific
How can you use “sequence-specific” in a sentence? Here are some example sentences to help you improve your vocabulary:
As the Y-box promoter element is crucial to the regulation of MHC class II gene expression, sequence-specific binding to this motif indicates a potential role for DEK in modulating normal and abnormal immune response.
Each ZAS gene encodes large sequence-specific DNA-binding proteins with Mr >250,000 that contain two widely separated of C 2 H 2 -type zinc finger pairs.
HLA -A and -B alleles were detected using low-resolution DNA-based typing (PCR/sequence-specific oligonucleotide probe) in index cases [ 16 ] . Control subjects were tested using the microdroplet lymphocytotoxicity test [ 8 ] ; subjects were evaluated using antisera that detected allele assignments described in the 9 thInternational Histocompatibility Workshop [ 17 ] . Because the levels of resolution of the DNA-based and serological typing methods we used are similar, alleles detected by these respective methods provide concordant allele assignments, with the exception of B*70 and B*71 that were not detected by serological methods.
HFE mutation analysis was performed as previously described [ 23 ] . A and B alleles were detected using low-resolution DNA-based typing (PCR/sequence-specific oligonucleotide probe) in probands [ 23 ] . Control subjects were tested using the microdroplet lymphocytotoxicity test [ 25 ] ; subjects were evaluated using antisera that detected allele assignments described in the 9 thInternational Histocompatibility Workshop [ 26 ] . Because the levels of resolution of the DNA-based and serological typing methods we used are similar, alleles detected by these respective methods provide concordant allele assignments, with the exception of B*70 and B*71 that were not detected by serological methods.
We hypothesized that DEK could bind in a sequence-specific manner to the Y-box motifs in the promoter regions of several class II MHC genes, and that gene- and allele-specific Y-box polymorphisms could affect DEK binding activity.
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