Words similar to sequence-specific
Example sentences for: sequence-specific
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To recap: by 1998—the year in which RNAi was reported—plant scientists had documented sequence-specific RNA degradation (PTGS), sequence-specific DNA methylation that triggered TGS, and RNA-directed DNA methylation.
1998), of a process called RNA interference (RNAi), in which dsRNA triggers sequence-specific mRNA degradation.
The tyrosine at this position (shared with TOX) is a DNA contact in the NHP6A-DNA complex [ 7 ] . Moreover, there is a conserved proline at position 70 of the sequence-specific DNA binding proteins that truncates the third alpha helix of the HMG-box structure allowing additional DNA contacts [ 24 27 28 ] . This proline is absent from TOX and the sequence-independent HMG-box proteins.
HLA -A and -B alleles were detected using low-resolution DNA-based typing (PCR/sequence-specific oligonucleotide probe) in index cases [ 16 ] . Control subjects were tested using the microdroplet lymphocytotoxicity test [ 8 ] ; subjects were evaluated using antisera that detected allele assignments described in the 9 thInternational Histocompatibility Workshop [ 17 ] . Because the levels of resolution of the DNA-based and serological typing methods we used are similar, alleles detected by these respective methods provide concordant allele assignments, with the exception of B*70 and B*71 that were not detected by serological methods.
In contrast to the ubiquitous DDRP, cellular RDRPs that are involved in PTGS so far have been detected only in eukaryotes [ 1 26 ] . The PTGS phenomenon covers a variety of complementarity-dependent silencing pathways, such as RNA interference (RNAi) in animals and slime mold, co-suppression (silencing of transgene and the corresponding endogenous genes) and virus gene resistance in plants, and quelling in fungi, all of which share a common mechanism of RNA turnover [ 28 37 38 39 40 ] . Essentially, double-stranded (ds) RNA, which is formed in these processes, triggers the activation of a sequence-specific RNA degradation system, which targets homologous RNAs [ 41 42 ] . The dsRNA is broken down by the Dicer enzyme into 21-25 nucleotide (nt) fragments called small interfering RNA or siRNAs [ 43 44 45 ] . The siRNAs subsequently associate with a complex of proteins called RISC and target homologous RNA by serving as guides for multiple rounds of RNA cleavage [ 45 46 ] .
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