Example sentences for: sequence-profile

How can you use “sequence-profile” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The hybrid-fold-recognition method, which combines sequence-profile analysis with alignment-based secondary-structure prediction [ 22] and the 3D-PSSM method [ 23] both suggested a likely α-amylase-like triosephosphate isomerase (TIM) barrel structure for this protein family.

  • To uncover their entire range of diversity, we initiated PSI-BLAST sequence-profile searches, seeded separately with the sequences of the Bro-N and Bro-C domains.

  • These connections are not, however, recovered in any sensitive sequence-profile or structural similarity searches.

  • Sequence-profile methods such as PSI-BLAST [ 1 ] or HMMER [ 2 ] are often used to detect distant homologs, and resources such as Prosite [ 3 ] , BLOCKS [ 4 ] and PFAM [ 5 ] are representative resources resulting from protein classification based on sequence patterns.

  • Here we use sequence-profile analysis and comparative genomics to show that the β-barrel domain of PRC-H defines a novel, widespread superfamily of β-barrel domains that is represented in several bacterial, plant and archaeal genomes.


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