Words similar to sequence-independent

Example sentences for: sequence-independent

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Similarly, TOX is more closely aligned with the sequence-independent HMG-box proteins than the sequence-specific transcription factors at position 65.
Murine HMGB1 and yeast NHP6A bind DNA in a sequence-independent fashion.
Although there are few amino acid positions within the HMG-box motif that are conserved throughout the HMG-box protein superfamily, there are highly conserved residues within sequence-dependent and sequence-independent subgroups [ 21 ] . The vast majority of HMG-boxes have a tryptophan in helix 2, often as part of a GXXW motif (where X denotes any amino acid) [ 3 5 ] . Similarly, TOX has a tryptophan at this position, although as part of the less commonly found AXXW sequence.
Based on sequence alignment comparison with other previously characterized HMG-box proteins, we predict that the TOX HMG-box subfamily will likely fall into the sequence-independent category of HMG-box proteins.
The tyrosine at this position (shared with TOX) is a DNA contact in the NHP6A-DNA complex [ 7 ] . Moreover, there is a conserved proline at position 70 of the sequence-specific DNA binding proteins that truncates the third alpha helix of the HMG-box structure allowing additional DNA contacts [ 24 27 28 ] . This proline is absent from TOX and the sequence-independent HMG-box proteins.