Words similar to sequence-independent

Example sentences for: sequence-independent

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The tyrosine at this position (shared with TOX) is a DNA contact in the NHP6A-DNA complex [ 7 ] . Moreover, there is a conserved proline at position 70 of the sequence-specific DNA binding proteins that truncates the third alpha helix of the HMG-box structure allowing additional DNA contacts [ 24 27 28 ] . This proline is absent from TOX and the sequence-independent HMG-box proteins.
TOX resembles sequence-independent HMG-box family members
The asparagine at position 10 makes contact with DNA in the hSRY-DNA complex [ 24 ] , as does the serine at this position in the NHP6A-DNA complex [ 7 ] . A hydrophobic residue at position 32 that can partially intercalate into DNA plays a role in DNA binding of some sequence-independent HMG-box proteins [ 7 25 26 ] . Position 32 is the hydrophobic residue phenylalanine in TOX, in contrast to the polar residues found at this position in SRY, SOX proteins and LEF-1.
Murine HMGB1 and yeast NHP6A bind DNA in a sequence-independent fashion.
Based on sequence alignment comparison with other previously characterized HMG-box proteins, we predict that the TOX HMG-box subfamily will likely fall into the sequence-independent category of HMG-box proteins.