Example sentences for: sequence-independent

How can you use “sequence-independent” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The asparagine at position 10 makes contact with DNA in the hSRY-DNA complex [ 24 ] , as does the serine at this position in the NHP6A-DNA complex [ 7 ] . A hydrophobic residue at position 32 that can partially intercalate into DNA plays a role in DNA binding of some sequence-independent HMG-box proteins [ 7 25 26 ] . Position 32 is the hydrophobic residue phenylalanine in TOX, in contrast to the polar residues found at this position in SRY, SOX proteins and LEF-1.

  • Based on sequence alignment comparison with other previously characterized HMG-box proteins, we predict that the TOX HMG-box subfamily will likely fall into the sequence-independent category of HMG-box proteins.

  • 1) are included in regions that have previously been shown together to be sufficient to confer sequence specificity to an HMG-box protein [ 23 ] . Positions 5 and 10 are proline and serine, respectively, in the sequence-independent DNA binders as well as in TOX.

  • TOX resembles sequence-independent HMG-box family members

  • Unlike other sequence-independent HMG-box proteins, which show ubiquitous tissue expression, we have previously shown that TOX has a highly regulated tissue and developmental expression profile.


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