Example sentences for: sequence-independent

How can you use “sequence-independent” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Murine HMGB1 and yeast NHP6A bind DNA in a sequence-independent fashion.

  • Similarly, TOX is more closely aligned with the sequence-independent HMG-box proteins than the sequence-specific transcription factors at position 65.

  • Based on sequence alignment comparison with other previously characterized HMG-box proteins, we predict that the TOX HMG-box subfamily will likely fall into the sequence-independent category of HMG-box proteins.

  • 1) are included in regions that have previously been shown together to be sufficient to confer sequence specificity to an HMG-box protein [ 23 ] . Positions 5 and 10 are proline and serine, respectively, in the sequence-independent DNA binders as well as in TOX.

  • The tyrosine at this position (shared with TOX) is a DNA contact in the NHP6A-DNA complex [ 7 ] . Moreover, there is a conserved proline at position 70 of the sequence-specific DNA binding proteins that truncates the third alpha helix of the HMG-box structure allowing additional DNA contacts [ 24 27 28 ] . This proline is absent from TOX and the sequence-independent HMG-box proteins.


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