Example sentences for: prostanoids

How can you use “prostanoids” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Prostanoids were measured by modified stable isotope dilution assays that used gas chromatography-negative ion-chemical ionization mass spectrometry as previously described [ 23 ] . Briefly, deuterium-labeled internal standards of PGE 2 , PGF 2α , TXB 2 , and 6-keto-PGF 1α were added to the supernatants with isopropyl alcohol.

  • Many cell types, including lung fibroblasts, contain cyclooxygenase (COX), a proximal enzyme in prostanoid production, and can generate prostanoids [ 19 ] . It has been previously reported that IPF lung fibroblasts have decreased COX-2 expression compared to normal lung fibroblasts and, hence, have decreased PGE 2 production [ 12 20 21 ] . Because of these findings and the fact that PGs are important fibroblast regulators, we sought to investigate whether abnormalities in COX-2 expression could be associated with an altered balance between profibrotic and antifibrotic PGs.

  • Radioligand binding studies were performed using various prostanoids and EP-receptor subtype-specific agonists to compete for PGE2 binding.

  • These assays do not show any cross-reactivity with other prostanoids, or rabbit and rat forms of IL-1 or IL-1Ra.

  • Ligand binding studies confirm that the rabbit EP2 receptor preferentially binds PGE 2 with significantly higher affinity than other endogenous prostanoids.


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