Words similar to prostacyclin
Example sentences for: prostacyclin
How can you use “prostacyclin” in a sentence? Here are some example sentences to help you improve your vocabulary:
Deletion of the prostacyclin receptor in mice does not cause spontaneous thrombosis, but rather enhances the response to thrombotic stimuli [9].
COX = cyclooxygenase; HF = human fibroblasts; NL = normal lungs; IPF = idiopathic pulmonary fibrosis; IFN = interferon; IL = interleukin; PG = prostaglandin; TX = thromboxane; PGI 2 = prostacyclin.
Prostanoids are important regulators of fibroblast function [ 5 6 7 8 9 ] . Prostaglandin (PG)E 2 is thought to have antifibrotic properties in vitro , but also can have proinflammatory effects both in vivo and in vitro [ 10 11 12 ] . Thromboxane (TX)A 2 increases proliferation, and DNA and RNA synthesis in several cell types, including fibroblasts and smooth muscle like glomerular mesangial cells [ 13 14 15 16 ] . Conversely, prostacyclin (PGI 2 ) decreases smooth muscle cell proliferation and collagen synthesis [ 17 18 ] .
We have found that fibroblasts cultured from normal and IPF human lungs have a significant and similar induction of the COX-2 enzyme when stimulated with IL-1β, but that IPF fibroblasts produced more thromboxane and had a significantly lower prostacyclin:thromboxane ratio.
The risk of thrombosis from valdecoxib has now been established [3,7], and this, together with its propensity rarely to cause Stevens-Johnson syndrome without a mitigating benefit over traditional nonsteroidal anti-inflammatory drugs, has led to its withdrawal from the market . The cardiovascular hazard of coxibs appears likely to be attributable to the suppression of COX-2-derived prostacyclin [1,8].
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