Words similar to proline-rich
Example sentences for: proline-rich
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One gene verified in this study, the small proline-rich protein 1A (Table 2), was characterized in detail by Bonilla et al, who show that it colocalizes with filamentous actin in membrane ruffles and augments axonal outgrowth [ 8 ] .
The mammalian proteins shares 89% similarity and 81% identity with Xenopus Prrp (for proline-rich RNA binding protein) [ 16 ] . The two RBDs are especially highly conserved.
8A,8B,8C), suggesting that the proline-rich region is not important for any of the observed patterns of localization of Boi1-GFP.
Cas is a protein which migrates with an apparent mass of approximately 130 kDa, with a N-terminal SH3 domain, a central substrate domain (SD) with up to 15 tyrosines which can be phosphorylated, a C-terminal region with a proline-rich region, and two tyrosine phosphorylation sites capable of binding Src kinases (Src binding domain (SBD)) [ 6 18 ] . The latter SBD domain regulates the ability of Src to activate the serum response element, as well as in the phosphorylation of the SD of Cas by Src [ 18 19 20 ] . The substrate domain controls adhesion and migration and the majority of the tyrosines within this domain are of the sequence YQXP (5) or YDXP (10), which when phosphorylated, bind to the adaptors c-crk, nck and AND-34 [ 16 21 22 23 ] . The importance of these molecules in Cas function is unclear, however c-crk seems to be critical in the regulation of adhesion and migration mediated by Cas.
Although physical binding of full length Btk to Src family kinases in vivo has not been reported, in vitro interactions have been demonstrated between proline-rich motifs in the amino-terminal sequence of Btk and the Src homology (SH) 3 domains of Src family kinases [ 25, 26].
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