Words similar to proline-rich
Example sentences for: proline-rich
How can you use “proline-rich” in a sentence? Here are some example sentences to help you improve your vocabulary:
Indeed, we have found that mutation of the proline-rich region did not abolish Rlk co-precipitation with either Fyn or Lck (data not shown), suggesting that interactions between these kinases may not occur solely through an SH3 mediated interaction, at least in the 293T expression system.
The proline-rich region of Btk has been found to bind to SH3 domains of Src family kinses in vitro.
In addition to a COOH-terminal PTK domain, Btk has an NH 2 - terminal pleckstrin homology (PH) domain, a proline-rich Tec homology domain, a Src-homology 3 (SH3) domain and a Src-homology 2 (SH2) domain.
Cas is a protein which migrates with an apparent mass of approximately 130 kDa, with a N-terminal SH3 domain, a central substrate domain (SD) with up to 15 tyrosines which can be phosphorylated, a C-terminal region with a proline-rich region, and two tyrosine phosphorylation sites capable of binding Src kinases (Src binding domain (SBD)) [ 6 18 ] . The latter SBD domain regulates the ability of Src to activate the serum response element, as well as in the phosphorylation of the SD of Cas by Src [ 18 19 20 ] . The substrate domain controls adhesion and migration and the majority of the tyrosines within this domain are of the sequence YQXP (5) or YDXP (10), which when phosphorylated, bind to the adaptors c-crk, nck and AND-34 [ 16 21 22 23 ] . The importance of these molecules in Cas function is unclear, however c-crk seems to be critical in the regulation of adhesion and migration mediated by Cas.
The mammalian proteins shares 89% similarity and 81% identity with Xenopus Prrp (for proline-rich RNA binding protein) [ 16 ] . The two RBDs are especially highly conserved.
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