Words similar to proliferative
Example sentences for: proliferative
How can you use “proliferative” in a sentence? Here are some example sentences to help you improve your vocabulary:
[ 11 12 13 14 ] . Kidney transplants between normal and transgenic Tg26 siblings suggested that specific HIV-1 proteins within the kidney, and not circulating factors, transform infected renal epithelium [ 13 ] . Indeed, HIV-1 transgenic mice generated with an HIV-1 proviral construct mutated in the Nef "PXXP" SH3-binding motif for Src-family kinases failed to develop nephropathy [ 31 ] , and a recent in vitro analysis of podocytes infected with single gene mutants of HIV-1 further suggest that Nef plays a central role in causing the proliferative phenotype in HIVAN [ 8 ] . Utilizing these same single gene mutant viruses, we showed here that Nef appears to be play a role in the up-regulation of cyclin D 1 by HIV-1 in vitro . Importantly, these single gene mutants do not exclude the possibility that other HIV-1 gene(s) may cooperate with nef to induce cyclin D1, particularly
The T790M mutation could also affect the kinase activity or alter the substrate specificity of mutant EGFRs, such that a proliferative advantage would be conferred upon cells bearing the mutation.
These tumors would most likely be highly proliferative, classified as high grade and late stage, hormone insensitive and potentially metastatic.
In vertebrate embryonic nervous systems, proliferative undifferentiated cells express Notch genes [ 13, 14, 15, 16, 17, 18, 19, 21, 24]; thus, Notch activity may maintain the neural precursor state.
Supporting evidence for the involvement of IGF-II in the proliferative effect resulting from loss of M6P/IGF2R function comes from studies of M6P/IGF2R knock-out mice.
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