Words similar to ph-
Example sentences for: ph-
How can you use “ph-” in a sentence? Here are some example sentences to help you improve your vocabulary:
Upregulation of p53 and WOX1 contributes, in part, to the PH-20-enhanced cytotoxic function of TNF [ 9 10 23 ] . WOX1 is a p53-binding protein.
Whether these TGF-β1-induced proteins restrict the ability of PH-20 to increase TNF cytotoxicity is unknown.
As summarized in Figure 1, PH-20 induces the expression of proapoptotic p53 and WOX1 [ 9 10 ] and downregulates antiapoptotic matrix inter-α-inhibitor [ 9 ] , thereby enhancing TNF susceptibility in L929 cells.
Although it is tempting to conclude that the pH- and heat-resistent dimerization we observe with VR1 results from a covalent interaction, we cannot rule out other explanations such as strong hydrophobic interactions.
In contrast, TGF-β1 protects L929 cells from TNF cytotoxicity by upregulating the expression of antiapoptotic TIAF1, TIF2 and a novel matrix protein [ 11 12 13 14 ] . TGF-β1 blocks PH-20-increased TNF susceptibility [ 15 ] . Likewise, PH-20 inhibits TGF-β1-induced TNF-resistance [ 15 ] . TGF-β1 suppresses PH-20-mediated ERK activation [ 16 ] ; however, the ERK activation is not related with PH-20-increased TNF susceptibility in L929 cells [ 15 ] . Whether the proapoptotic p53 and WOX1 block the function of antiapoptotic TIAF1 and TIF2 is not known.
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