Words similar to ph-
Example sentences for: ph-
How can you use “ph-” in a sentence? Here are some example sentences to help you improve your vocabulary:
Bovine testicular PH-20 enhances TNF sensitivity in L929 cells by increasing the expression of proapoptotic p53 and WOX1 [ 9 10 ] . The ability of Hyal-1 and Hyal-2 to induce the expression of p53 and WOX1 in L929 cells was examined.
PH-20 blocks TGF-β1-mediated growth suppression of epithelial cells [ 8 15 ] . Additionally, PH-20 rapidly activates ERK in L929 cells and TGF-β1 reduces the PH-20-induced ERK activation [ 16 ] . In contrast, TGF-β1 synergistically increases PH-20-mediated inhibition of staurosporine apoptosis [ 16 ] . Thus, PH-20 and TGF-β1 are physiological antagonists for only certain cellular responses.
TGF-β family proteins, including β1,β2 and β3, induce TNF-resistance and suppress the PH-20 effect of increasing TNF cytotoxicity in murine L929 fibroblasts [ 8 11 ] . TGF-β1 induces a novel extracellular matrix protein that prevents TNF-mediated cell death and blocks the activation of extracellular signal-regulated kinase (ERK; also known as p42/44 mitogen-activated protein kinase, p42/44 MAPK) in L929 cells [ 8 12 ] . Additionally, TGF-β1 induces the expression of TIAF1 (TGF-β-induced antiapoptotic factor) [ 13 ] and TIF2 (TGF-β-induced factor 2) [ 14 ] that inhibit TNF cytotoxicity.
Exogenous bovine testicular hyaluronidase PH-20 stimulates rapid activation of c-Jun N -terminal kinases (JNK1 and JNK2) in L929 cells [ 16 ] . In contrast, the stably expressed Hyal-1 and Hyal-2 could not mediate constitutive activation of JNK1 and JNK2 in L929 cells (data not shown).
Also, PH-20 rapidly activates ERK and c-Jun N -terminal kinase (JNK1 and JNK2) [ 16 ] . Whether these signaling events lead to induction of p53 and WOX1 is unknown.
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