Words similar to ph-
Example sentences for: ph-
How can you use “ph-” in a sentence? Here are some example sentences to help you improve your vocabulary:
These observations are consistent with our previous finding that exogenous bovine testicular hyaluronidase PH-20 enhances TNF cytotoxicity in various cancer cells, and that TGF-β1 blocks the increased TNF cytotoxicity [ 8 15 ] . As summarized in the Figure 8, the underlying mechanisms whereby Hyal-2 induces TNF cytotoxicity appear to be associated with 1) Hyal-2 induction of the proapoptotic WOX1, 2) Hyal-2 migration to the mitochondria during apoptosis, and 3) the prolonged period of IκBα degradation and NF-κB activation in TNF-treated Hyal-2-expressing cells.
TGF-β1 inhibits epithelial cell growth but promotes fibroblast growth [ 15 ] . TGF-β1 inhibition of epithelial cell growth is blocked by bovine testicular PH-20 [ 15 ] . In agreement with our previous observations [ 11 ] , TGF-β1 promoted L929 cell growth by approximately 20% in 24-48 hr (Fig.
As summarized in Figure 1, PH-20 induces the expression of proapoptotic p53 and WOX1 [ 9 10 ] and downregulates antiapoptotic matrix inter-α-inhibitor [ 9 ] , thereby enhancing TNF susceptibility in L929 cells.
PH-20 blocks TGF-β1-mediated growth suppression of epithelial cells [ 8 15 ] . Additionally, PH-20 rapidly activates ERK in L929 cells and TGF-β1 reduces the PH-20-induced ERK activation [ 16 ] . In contrast, TGF-β1 synergistically increases PH-20-mediated inhibition of staurosporine apoptosis [ 16 ] . Thus, PH-20 and TGF-β1 are physiological antagonists for only certain cellular responses.
The Sperm Adhesion Molecule 1 (SPAM1 or PH-20) is a glycosyl-phosphatidylinositol (GPI)-linked protein found on all mammalian spermatozoa that have been examined, and has been reported to play multiple roles in fertilization [ 1 ] . Although a recent gene targeting study indicates that in mice, which have four active non-somatic hyaluronidases, Spam1 is not essential for fertilization [ 2 ] ; this is unlikely to be the case in humans where SPAM1 is the only such hyaluronidase present.
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