Words similar to ph-

Example sentences for: ph-

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Also, PH-20 rapidly activates ERK and c-Jun N -terminal kinase (JNK1 and JNK2) [ 16 ] . Whether these signaling events lead to induction of p53 and WOX1 is unknown.
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PH-20 blocks TGF-β1-mediated growth suppression of epithelial cells [ 8 15 ] . Additionally, PH-20 rapidly activates ERK in L929 cells and TGF-β1 reduces the PH-20-induced ERK activation [ 16 ] . In contrast, TGF-β1 synergistically increases PH-20-mediated inhibition of staurosporine apoptosis [ 16 ] . Thus, PH-20 and TGF-β1 are physiological antagonists for only certain cellular responses.
PH-20 induces the expression of proapoptotic p53 [ 9 ] and WOX1 (WW domain-containing oxidoreductase; also known as WWOX or FOR) [ 10 ] , which contributes to the increased TNF cytotoxic effect.
The Sperm Adhesion Molecule 1 (SPAM1 or PH-20) is a glycosyl-phosphatidylinositol (GPI)-linked protein found on all mammalian spermatozoa that have been examined, and has been reported to play multiple roles in fertilization [ 1 ] . Although a recent gene targeting study indicates that in mice, which have four active non-somatic hyaluronidases, Spam1 is not essential for fertilization [ 2 ] ; this is unlikely to be the case in humans where SPAM1 is the only such hyaluronidase present.