Words similar to pcv
Example sentences for: pcv
How can you use “pcv” in a sentence? Here are some example sentences to help you improve your vocabulary:
Resistance to acyclovir (ACV) or penciclovir (PCV) generally arises by a single base mutation in either the HSV thymidine kinase (TK) or DNA polymerase (Pol) gene [for a review, see reference [ 5 ] ]. Unlike Pol, TK is not essential for virus replication in cell culture [ 7 ] , although in vivo analyses implicate it in HSV virulence, pathogenicity and reactivation from latency [ 4 8 16 22 ] . Since ACV and PCV are dependent upon HSV TK for monophosphorylation, an event obligatory for the formation of the active triphosphate inhibitor [ 14 ] , ACV risolates often exhibit high levels of cross-resistance to PCV [ 2 3 ] .
The clonal isolates were tested for susceptibility to using the PRA and were found to be highly resistant to ACV (ACV IC 50 s > 25 μg/ml) and PCV (Table 4; PCV IC 50 s > 25 μg/ml), although susceptible to foscarnet.
with minor modifications [ 13 ] as reported previously [ 17 ] . Briefly, six serial 10-fold dilutions of virus were inoculated onto MRC-5 cells in the absence of antiviral drug or in the presence of either ACV or PCV at a concentration of antiviral 10 times higher than the average IC 50 for wild type parental HSV-1 and HSV-2, respectively.
Although virus recovered at passage 4 from one of five mice treated with VCV (14-P4) was clearly resistant in the PRA (IC 50 s 8.3 and 9.5 for PCV and ACV, respectively), the preceding and the subsequent isolates were sensitive according to the criteria for defining resistance.
Generally, the proportion of PCV rvirus varied only two-fold between tests when compared to the control virus, ranging from 0.004 to 0.009% (data not shown); however, three serial samples in the VCV-treatment group, 14-P2, 14-P3 and 14-P4, clearly showed a substantial increase in the proportion of resistant virus relative to the wild type control, specifically an 11-, 300- and 8800-fold increase, respectively (14-P2, 0.002%; 14-P3, 2%; and 14-P4, 44% PCV r).
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