Words similar to overexpression
Example sentences for: overexpression
How can you use “overexpression” in a sentence? Here are some example sentences to help you improve your vocabulary:
It is possible that overexpression of the putative transporter encoded by Sugar baby could increase life span by increasing uptake of a particular sugar and altering energy metabolism pathways.
Nonetheless, E2F is inactivated and/or downregulated upon progression to S phase, a regulatory feature that appears critical as E2F overexpression or ectopic activation induces apoptosis both in mammalian cells and in flies [ 12 ] [ 13 ] [ 14 ] [ 15 ] . Inactivation of the DNA-binding activity of E2F-1 by the cyclin A/Cdk complex has been shown to be critical for proper S phase progression [ 16 ] . In mammalian cells, E2F-1 is also subject to proteasome-mediated degradation [ 17 ] [ 18 ] [ 19 ] and recent evidence indicates that E2F-1 degradation occurs in S phase [ 20 ] . Control of E2F-1 stability has also been linked to its association with the F-box protein Skp2 [ 20 ] but this has not been tied to a specific phase of the cell cycle.
Together these results indicate that mCul1 overexpression leads to a Cul1 dominant negative action that reduces SCF function.
GAL -driven overexpression of Dbf2/(GST-Mob1) protein kinase complex did not dislodge Cdc14 from the nucleolus (data not shown).
Several possible mechanisms have been suggested to explain this activation of AR, including mutations in the gene encoding AR that alter the specificity for androgens, overexpression of the AR protein itself, cross-talk to other signal transduction pathways, and altered levels or activity of coactivators [ 21 22 23 ] . Several groups including ours have demonstrated a role of activated Stat3 in the proliferation and survival of prostate cancer cells by a mechanism that involves the AR [ 24 25 26 27 28 ] .
Loading...