Example sentences for: overexpression

How can you use “overexpression” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Because a high level of ectopic expression of E2F is known to induce apoptosis [ 12 ] [ 13 ] , these results suggest that mCul1 overexpression might interfere with normal E2F downregulation.

  • PIP3 is involved in the insulin-like signaling pathway that affects life span in Drosophila and C. elegans [ 53], and it will be of interest to determine if fwd overexpression is somehow affecting this pathway.

  • Several possible mechanisms have been suggested to explain this activation of AR, including mutations in the gene encoding AR that alter the specificity for androgens, overexpression of the AR protein itself, cross-talk to other signal transduction pathways, and altered levels or activity of coactivators [ 21 22 23 ] . Several groups including ours have demonstrated a role of activated Stat3 in the proliferation and survival of prostate cancer cells by a mechanism that involves the AR [ 24 25 26 27 28 ] .

  • The Tie receptors and the ligands Ang-1 and Ang-2 appear to be involved in the later stages of vessel growth and remodeling [ 8 13 ] . Transgenic mice with gene deletions [ 7 8 13 ] or overexpression of Ang-2 [ 6 ] exhibit early embryonic lethality secondary to defects in the developing vasculature.

  • In addition, lines in which PdL causes overexpression of a gene with large negative effects on life span should have been eliminated by this step.


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