Example sentences for: npc
How can you use “npc” in a sentence? Here are some example sentences to help you improve your vocabulary:
Second, we sought to preferentially isolate mutants that decrease overall NPC number versus inhibiting the incorporation of the single GFP-Nup.
Nic96p and Nup170p are two of the most abundant nucleoporins [ 5 31 ] , the characterized nic96 and nup170 mutants do not result in gross morphological NPC perturbations (e.g.
De novo assembly into intact NEs occurs during cell and nuclear growth to maintain a constant NPC density [ 10 ] . In cells undergoing an open mitosis, NPCs are also re-assembled with the formation of the NE at the end of mitosis [ 11 ] . The mechanisms controlling membrane fusion during pore formation and the steps for assembly of the distinct NPC substructures have not been fully elucidated.
The phenotypes observed in sec13 and sec23 mutants might indicate that COPII vesicles and/or a vesicular biogenesis step is required for NPC formation; however, there are at least two indirect mechanisms by which NPC structure may be changed in these mutants.
The initial isolation of multiple sec mutants from our screen that was designed to isolate mutants in NPC assembly and localization raised the question of whether any of the mutants were specific for defects in NPC assembly/structure.
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