Words similar to npc

Example sentences for: npc

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In comparison to our previous genetic screen with a strain expressing only GFP-Nup49p [ 26 ] , these results suggest that increasing the number of GFP-Nups as reporters for NPC integrity effectively increases the likelihood of obtaining a panel of mutants defective in global NPC assembly, stability, and localization.
This strategy was based on the ability to functionally express GFP-nucleoporin fusions, and the assumption that NPC a ssembly/mislocalization mutants expressing a GFP-nucleoporin would have distinct fluorescence properties [ 26 ] . In wild type yeast cells, fluorescence microscopy localization of proteins at NPCs appears as punctate staining of virtually the entire nuclear rim circumference (see Figure 2).
Taken together, the work to date supports a framework wherein a network of in vivo interactions mediate NPC biogenesis, structural integrity, and proper localization in the NE.
The npa1-3/sec23 and npa1-7/sec23 mutants may be unique alleles that preferentially affect NPC assembly versus secretion.
NIC96 is an essential nucleoporin and a member of multiple biochemically distinct NPC subcomplexes [ 29 30 ] . NUP170 , while not essential, is physically and genetically linked to a distinct subset of nucleoporins [ 31 32 33 34 ] . The rationale for using NIC96 and NUP170 are several-fold.