Words similar to nf-y
Example sentences for: nf-y
How can you use “nf-y” in a sentence? Here are some example sentences to help you improve your vocabulary:
The DQA1*0501 allele is strongly associated with early-onset pauciarticular JRA in Northern European populations [ 23 24 ] and with increased risk for juvenile dermatomyositis [ 25 ] and Sjögren's syndrome with high autoantibody production [ 26 27 ] . In our proposed model, aberrant class II MHC regulation could result from altered DEK binding and/or interaction with NF-Y, and aberrant class II expression may alter or enhance reactivity against DEK-derived or other self peptides.
Both DEK and NF-Y participate in the HLA-DQA1Y-box binding complex
NF-Y binding to the MHC class II gene Y box anchors a complex assembly of nuclear proteins that occupies several regulatory elements over a great distance [ 20 21 22 ] . In the DQA1 promoter Y box, a reverse CCAAT motif with a partially overlapping TG-rich sequence shares sequence identity with the HIV-2 DEK-binding site at 7 of 10 positions (Fig.
Another is that NF-Y and DEK both participate in the HLA-DQA*0101 Y-box binding complex, which coordinates DQ protein expression.
Participation of both DEK and NF-Y in the DQA1 Y-box binding complex was confirmed by using high-titer anti-DEK antiserum (gift of W Szer [ 9 ] ) and monoclonal antibody to the NF-YA subunit of the Y-box binding factor (gift of JP-Y Ting) to further retard the mobility of the DQA1 Y-box binding complex ('supershifting') (Fig.
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