Example sentences for: nf-y

How can you use “nf-y” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Both DEK and NF-Y participate in the HLA-DQA1Y-box binding complex

  • The NF-Y transcription factor adds further complexity to transcriptional regulation since it can interact and modulate the expression of SREBP-1c target genes containing Y-box motifs, such as those found in Fasn [ 37 ] . Mutating the NF-Y binding site in Fasn relieved LC-PUFA-induced Fasn down regulation [ 39 ] . Nfyb was differentially expressed after dietary LC-PUFA addition (1.

  • Another is that NF-Y and DEK both participate in the HLA-DQA*0101 Y-box binding complex, which coordinates DQ protein expression.

  • The DQA1*0501 allele is strongly associated with early-onset pauciarticular JRA in Northern European populations [ 23 24 ] and with increased risk for juvenile dermatomyositis [ 25 ] and Sjögren's syndrome with high autoantibody production [ 26 27 ] . In our proposed model, aberrant class II MHC regulation could result from altered DEK binding and/or interaction with NF-Y, and aberrant class II expression may alter or enhance reactivity against DEK-derived or other self peptides.

  • NF-Y binding to the MHC class II gene Y box anchors a complex assembly of nuclear proteins that occupies several regulatory elements over a great distance [ 20 21 22 ] . In the DQA1 promoter Y box, a reverse CCAAT motif with a partially overlapping TG-rich sequence shares sequence identity with the HIV-2 DEK-binding site at 7 of 10 positions (Fig.


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