Words similar to nf-y
Example sentences for: nf-y
How can you use “nf-y” in a sentence? Here are some example sentences to help you improve your vocabulary:
Both DEK and NF-Y participate in the HLA-DQA1Y-box binding complex
The DQA1*0501 allele is strongly associated with early-onset pauciarticular JRA in Northern European populations [ 23 24 ] and with increased risk for juvenile dermatomyositis [ 25 ] and Sjögren's syndrome with high autoantibody production [ 26 27 ] . In our proposed model, aberrant class II MHC regulation could result from altered DEK binding and/or interaction with NF-Y, and aberrant class II expression may alter or enhance reactivity against DEK-derived or other self peptides.
Consistent protection is also seen at position 2, adjacent to the A-for-G substitution that diverges from the Y-box consensus sequence, although there is no protection of the divergent base itself at position 3. DNase I protection by recombinant DEK extends over the length of the Y-box sequence, including bases within the NF-Y binding site (reverse CCAAT sequence), again suggesting that the two proteins may interact.
NF-Y binding to the MHC class II gene Y box anchors a complex assembly of nuclear proteins that occupies several regulatory elements over a great distance [ 20 21 22 ] . In the DQA1 promoter Y box, a reverse CCAAT motif with a partially overlapping TG-rich sequence shares sequence identity with the HIV-2 DEK-binding site at 7 of 10 positions (Fig.
Divergence of the HLA-DQA1*0501 Y-box sequence at one position within the required NF-Y binding site reduces its ability to compete with the DRA Y-box probe (Fig.