Words similar to nf-y
Example sentences for: nf-y
How can you use “nf-y” in a sentence? Here are some example sentences to help you improve your vocabulary:
The NF-Y transcription factor adds further complexity to transcriptional regulation since it can interact and modulate the expression of SREBP-1c target genes containing Y-box motifs, such as those found in Fasn [ 37 ] . Mutating the NF-Y binding site in Fasn relieved LC-PUFA-induced Fasn down regulation [ 39 ] . Nfyb was differentially expressed after dietary LC-PUFA addition (1.
The DQA1*0501 allele is strongly associated with early-onset pauciarticular JRA in Northern European populations [ 23 24 ] and with increased risk for juvenile dermatomyositis [ 25 ] and Sjögren's syndrome with high autoantibody production [ 26 27 ] . In our proposed model, aberrant class II MHC regulation could result from altered DEK binding and/or interaction with NF-Y, and aberrant class II expression may alter or enhance reactivity against DEK-derived or other self peptides.
In this study, we examine the characteristics of DEK binding to the Y-box sequences of DQA1*0101, DQA1*0501, DRA, DQB , and DRB . We also confirm participation of DEK with NF-Y in the DQA1 Y-box binding complex and localize specific DEK binding within this sequence.
Participation of both DEK and NF-Y in the DQA1 Y-box binding complex was confirmed by using high-titer anti-DEK antiserum (gift of W Szer [ 9 ] ) and monoclonal antibody to the NF-YA subunit of the Y-box binding factor (gift of JP-Y Ting) to further retard the mobility of the DQA1 Y-box binding complex ('supershifting') (Fig.
Consistent protection is also seen at position 2, adjacent to the A-for-G substitution that diverges from the Y-box consensus sequence, although there is no protection of the divergent base itself at position 3. DNase I protection by recombinant DEK extends over the length of the Y-box sequence, including bases within the NF-Y binding site (reverse CCAAT sequence), again suggesting that the two proteins may interact.
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