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Example sentences for: nf-il-

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Consistent with RSV and TNFα inducing functionally distinct NF-κB binding complexes, AP-1 was recently shown to be the preferential cooperative partner with NF-κB in RSV-induced IL-8 expression [ 46 ] , whereas in TNFα-induced expression NF-κB cooperates preferentially with NF-IL-6 [ 18 19 22 ] . Apparently, the stimulus-specific gene regulation of chemokines is complex involving differential cooperativity of redox sensitive and redox resistant NF-κB complexes with other transcription factors to form unique higher order transcription complexes.
TNF-α is a well-characterized, potent inducer of IL-8 transcription and an anti-apoptotic agent [ 30 31 32 ] . Roebuck provides a detailed analysis of IL-8 promoter structure including a promoter recruitment mechanism which involves TNF-α and the cooperativity of NF-kB and NF-IL-6 binding sites [ 4 32 ] . TNF-α exerts many of its effects through TNFR-1 and TNFR-2 receptors, thus co-expression of these receptors with IL-8 might be anticipated.