Example sentences for: nf-kb

How can you use “nf-kb” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The MAdCAM-1 promoter has several NF-kB binding sites [ 32], and are necessary to induce MAdCAM-1 expression.

  • For example, PPARγ is involved in a positive feedback mechanism that induces the formation of foam cells [ 23 ] . On the other hand, activation of PPARγ was shown to inhibit monocyte [ 24 ] and macrophage [ 25 ] inflammatory responses by preventing the activation of nuclear transcription factors, such as NF-kB (nuclear factor-kappa B), AP-1 (activator protein-1) and STAT 1 (signal transducer and activator of transcription 1).

  • We have described in vitro that exogenous IL-10 can block the expression of MAdCAM-1 in response to TNF-α, and attenuates lymphocyte adhesion to lymphatic node derived endothelium under cytokine stimulating conditions via NF-kB inhibition [ 5 ] . The purpose of the current study was to show that induction of endothelial expression of IL-10 through an IL-10 expression vector attenuates MAdCAM-1 expression in response to TNF-α and optimistically suggests the possibility of targeted Th2-cytokine gene therapy in IBD.

  • Inhibition of the signal transducer and activator of transcription 1 (STAT-1) and the nuclear factor kB (NF-kB) may be partially responsible for the inhibitory effects.

  • Figure 2Cshows that TNF-α (20 ng/ml) significantly increased nuclear translocation of p65, a subunit of the p50/p65 NF-kB complex.


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