Words similar to nf-kb
Example sentences for: nf-kb
How can you use “nf-kb” in a sentence? Here are some example sentences to help you improve your vocabulary:
Similarly, GSNO also reduced NF-kB activation (as measured by EMSA).
There are at least two regulating pathways in ECAM expression, one is a cytokine-dependent pathway which is widely studied and the other is cytokine-independent [ 58 ] . IL-10 apparently prevents cytokine-induced NF-kB binding activity to the ECAM promoter [ 59 ] and blocks the excessive expression of ECAMs in cytokine-mediated inflammatory conditions.
TNF-α is a well-characterized, potent inducer of IL-8 transcription and an anti-apoptotic agent [ 30 31 32 ] . Roebuck provides a detailed analysis of IL-8 promoter structure including a promoter recruitment mechanism which involves TNF-α and the cooperativity of NF-kB and NF-IL-6 binding sites [ 4 32 ] . TNF-α exerts many of its effects through TNFR-1 and TNFR-2 receptors, thus co-expression of these receptors with IL-8 might be anticipated.
Therefore, NO might limit NF-kB activation through pathways independent of IkB-a.
It has previously been shown that IL-8 mRNA induction was seen less then 1 h after Tat (72aa) stimulation, and levels remained elevated for up to 24 h, leading to IL-8 protein production [ 102 ] . Along these lines, we have previously shown that the IL-8 gene is expressed in a cell cycle-dependent manner in cells that express the Tat protein, and the induction is during the S phase of the cell cycle and regulated by stable NF-kB binding to the IL-8 promoter [ 103 ] . When looking for IL-8 at the G1/S border, we found that all Tat containing cells, including PBMCs that were treated with exogenous Tat showed an up-regulation of IL-8 in the supernatant (Figure 4), further implying that results obtained from the H9/Tat system may infact be of general physiological relevance in vivo.
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