Words similar to nf-kb
Example sentences for: nf-kb
How can you use “nf-kb” in a sentence? Here are some example sentences to help you improve your vocabulary:
There are at least two regulating pathways in ECAM expression, one is a cytokine-dependent pathway which is widely studied and the other is cytokine-independent [ 58 ] . IL-10 apparently prevents cytokine-induced NF-kB binding activity to the ECAM promoter [ 59 ] and blocks the excessive expression of ECAMs in cytokine-mediated inflammatory conditions.
Figure 2Cshows that TNF-α (20 ng/ml) significantly increased nuclear translocation of p65, a subunit of the p50/p65 NF-kB complex.
It has previously been shown that IL-8 mRNA induction was seen less then 1 h after Tat (72aa) stimulation, and levels remained elevated for up to 24 h, leading to IL-8 protein production [ 102 ] . Along these lines, we have previously shown that the IL-8 gene is expressed in a cell cycle-dependent manner in cells that express the Tat protein, and the induction is during the S phase of the cell cycle and regulated by stable NF-kB binding to the IL-8 promoter [ 103 ] . When looking for IL-8 at the G1/S border, we found that all Tat containing cells, including PBMCs that were treated with exogenous Tat showed an up-regulation of IL-8 in the supernatant (Figure 4), further implying that results obtained from the H9/Tat system may infact be of general physiological relevance in vivo.
In this model, the mechanism through which NO donors limit inflammation is by NF-kB inhibition, since these NO donors effectively block p65 translocation into the nucleus.
The effects of NO donors appear to reflect their ability to prevent the nuclear translocation of NF-kB.
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