Example sentences for: nf-kb

How can you use “nf-kb” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • TNF-α is a well-characterized, potent inducer of IL-8 transcription and an anti-apoptotic agent [ 30 31 32 ] . Roebuck provides a detailed analysis of IL-8 promoter structure including a promoter recruitment mechanism which involves TNF-α and the cooperativity of NF-kB and NF-IL-6 binding sites [ 4 32 ] . TNF-α exerts many of its effects through TNFR-1 and TNFR-2 receptors, thus co-expression of these receptors with IL-8 might be anticipated.

  • SP1 and possibly AP2, Adh1 (ETF), PEA3 sites [ 32] which could also contribute to NF-kB dependent gene activation and might participate in NO mediated MAdCAM-1 regulation by cytokines.

  • In that report, NO was found to induce IκB synthesis through activation of its promoter, therefore, increased IkB-a might also contribute to NF-kB inhibition . Several other possible pathways, e.g. p38, p42/44 MAPK and transcription factors, e.g.

  • For example, PPARγ is involved in a positive feedback mechanism that induces the formation of foam cells [ 23 ] . On the other hand, activation of PPARγ was shown to inhibit monocyte [ 24 ] and macrophage [ 25 ] inflammatory responses by preventing the activation of nuclear transcription factors, such as NF-kB (nuclear factor-kappa B), AP-1 (activator protein-1) and STAT 1 (signal transducer and activator of transcription 1).

  • Therefore, NO might limit NF-kB activation through pathways independent of IkB-a.


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