Example sentences for: nf-κb

How can you use “nf-κb” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Transcription factor genes that were modulated by IL-1β included members from the NF-κB family (relB, p100/p52, p105/p50, IκB-ε, c-rel, and p65), the AP-1 family (fra-1 and junB), and the ETS family (ets-1).

  • Readouts have included calcium mobilization and apoptosis [ 11, 37], MAPK activation [ 9, 38] and NF-κB activation [ 41].

  • The transcription factor NF-κB plays a critical role in controlling expression of downstream target genes in immune and inflammatory responses, development, and apoptosis [ 30 ] . Important advances have been made in understanding the signal transduction cascades that control NF-κB activation.

  • We have recently reported the role of the inhibitor of NF-κB (IκB) family member Bcl-3 in IL-1-induced MMP-1 expression [ 24 ] . Here we show that overexpression of Bcl-3 can partly abrogate CDDO's inhibitory effects on MMP-1 in SW-1353 cells, suggesting that Bcl-3 might be a target for CDDO.

  • When activated, pattern recognition receptors induce intracellular signaling via the transcription factor NF-κB, resulting in the activation of genes involved in host defense.


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