Words similar to nfat

Example sentences for: nfat

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Although such domain-based investigations have been constructive in studying the activity and the properties of the NFAT DNA-binding domains, a biochemical analysis of transcriptional activation and regulated nuclear association of NFAT necessitated the characterization of full-length proteins.
Both proteins were competent for binding a high affinity NFAT site when tested in electrophoretic mobility shift assays (Figure 4B).
To date, biochemical analysis of NFATp and other NFAT members has been conducted using only portions and not the full-length versions of these proteins.
Finally, it should be noted that a recent study using cell lines raised the possibility that SN50's action is not specific to NF-κB [ 61 62 ] . SN50 is composed of the NLS for NF-κB p50 and was believed to specifically block NF-κB p50/p65 nuclear translocation by binding the NLS receptor complex and preventing transport through the nuclear pore [ 33 34 35 ] . However, Torgerson and coworkers [ 61 ] have shown that SN50 treatment inhibited nuclear transport of transcription factors NFAT, AP-1, STAT1, and NF-κB at a high dose of 210 μg/ml in Junkrat cells.
For example, even though the NFAT sites in the DNA template used in the transcription experiments in Figures 3Aand 3Bwere high affinity NFAT binding sites that were not part of a composite element, it remained possible that AP-1 proteins in the nuclear extract contributed to the activation observed.