Example sentences for: nfat

How can you use “nfat” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • p(NFAT) 3 -E1b-CAT, used as template DNA in the in vitro transcription assays, was created by inserting three direct copies of the murine IL-4 high affinity NFAT site (region -82 to -64 of the murine IL-4 promoter) into the Xba I site of plasmid E1b-CAT.

  • NFATc appears to be critical for proper cardiac muscle-cell differentiation [ 7], and NFAT3 functions in cardiac hypertrophy [ 8].

  • Our experiments in a reconstituted transcription system lacking contaminating AP-1 proteins and using DNA templates with high affinity NFAT sites demonstrate that NFATp can function as a transcriptional activator on its own.

  • Although such domain-based investigations have been constructive in studying the activity and the properties of the NFAT DNA-binding domains, a biochemical analysis of transcriptional activation and regulated nuclear association of NFAT necessitated the characterization of full-length proteins.

  • Recovery of smaller, soluble, truncated forms of NFAT proteins is feasible relative to the more difficult task of isolating active forms of full-length NFAT proteins.


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