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Example sentences for: nfat

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For example, in B cells, NF-κB is activated by a large, transient calcium flux, whereas NFAT is activated by a low, sustained calcium plateau [ 35].
Sequence comparison of NFAT proteins revealed that the DNA-binding domain and a region referred to as the NFAT homology region (NHR) share sequence similarity, while other regions of the NFAT proteins share little or no sequence similarity (a schematic of NFATp is shown in Figure 1A) [ 1].
It is not possible to assess the true transactivation function of NFAT proteins in reporter assays that use a promoter comprised of NFAT/AP-1 composite elements in cells with high levels of endogenous AP-1 proteins.
The binding reactions were performed in a total volume of 10 μl in a buffer consisting of 10 mM Tris (pH 7.9), 50 mM KCl, 10% glycerol, 50 μg/ml BSA, 1 mM DTT, 10 mM Hepes, 5 mM MgCl 2 , 10 μg/ml calf thymus DNA, and 1.25 fmoles of double-stranded oligonucleotide bearing a high-affinity NFAT site (murine IL-4 promoter from -82 to -64).
For example, even though the NFAT sites in the DNA template used in the transcription experiments in Figures 3Aand 3Bwere high affinity NFAT binding sites that were not part of a composite element, it remained possible that AP-1 proteins in the nuclear extract contributed to the activation observed.