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Example sentences for: nfat

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Other notable findings point to additional signaling proteins (CAMK, p38MAPK, and AMPK) and transcription factors (PGC-1, MEF2, ATF2, PPARs) active in pathways that intersect with calcineurin–NFAT signaling [31,43,44,45,46,47,48] (see Figure 2).
The C-terminal regions of NFAT proteins are unique in sequence and may be responsible for functional differences among NFAT family members.
NFAT5 is involved in the transcriptional regulation of osmotic stress response genes [ 9, 10].
Each reaction contained 50 ng of either p(NFAT) 3 -E1b-CAT, or p(NFAT) 3 -MLP-G-less.
Finally, it should be noted that a recent study using cell lines raised the possibility that SN50's action is not specific to NF-κB [ 61 62 ] . SN50 is composed of the NLS for NF-κB p50 and was believed to specifically block NF-κB p50/p65 nuclear translocation by binding the NLS receptor complex and preventing transport through the nuclear pore [ 33 34 35 ] . However, Torgerson and coworkers [ 61 ] have shown that SN50 treatment inhibited nuclear transport of transcription factors NFAT, AP-1, STAT1, and NF-κB at a high dose of 210 μg/ml in Junkrat cells.