Words similar to nfat

Example sentences for: nfat

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In biochemical experiments the DNA-binding domains of NFAT proteins (with the exception of NFAT5) are sufficient for cooperative DNA-binding in association with Fos/Jun heterodimers [ 4, 10, 11].
Calcineurin, a Ca 2+ /calmodulin-activated phosphatase implicated in nerve activity-dependent fiber-type specification in skeletal muscle, directly controls the phosphorylation state of the transcription factor NFAT, allowing for its translocation to the nucleus and leading to the activation of slow-type muscle proteins in cooperation with myocyte enhancer factor 2 (MEF2) proteins and other regulatory proteins (Chin et al.
The transactivation properties of the two proteins were tested by in vitro transcription using the reconstituted transcription system and a DNA template consisting of three high affinity NFAT sites upstream of the adenovirus major late core promoter and a 200 bp G-less cassette.
p(NFAT) 3 -E1b-CAT, used as template DNA in the in vitro transcription assays, was created by inserting three direct copies of the murine IL-4 high affinity NFAT site (region -82 to -64 of the murine IL-4 promoter) into the Xba I site of plasmid E1b-CAT.
We also found that HA-NFATp could be purified from cell extracts by DNA affinity chromatography using an immobilized double stranded oligonucleotide containing two high affinity NFAT binding sites, followed by elution with NaCl (Figure 1C).