Words similar to nf-κb-mediated

Example sentences for: nf-κb-mediated

How can you use “nf-κb-mediated” in a sentence? Here are some example sentences to help you improve your vocabulary:

Several lines of evidence indicate that NF-κB is constitutively activated in cancer cells, suggesting that it plays an important role in tumorigenesis [ 30 ] . Activated glucocorticoid receptors have been shown to repress NF-κB-mediated gene expression [ 31 ] , and to cause a significant reduction in nuclear levels of p65 protein, a subunit of NF-κB [ 31 ] . A variety of mitogens, cytokines, and reactive oxygen intermediates have been shown to rapidly cause the translocation of NF-κB to the nucleus [ 30 31 32 ] , and the ability of dexamethasone to interfere with this translocation is blocked by prior treatment with the glucocorticoid antagonist RU 486 [ 30 ] . Based on these findings, it is plausible to speculate that exposure to RU 486 may interfere with the function of endogenous glucocorticoids as regulators of cell cycle, allowing the initiation and progression of malignant transformation of liver cells.
Our results indicate that NF-κB-mediated transcription is directly or indirectly critical to embryonic SMG developmental homeostasis.
As noted above, CORT/GR binding both activates specific gene expression and transrepresses NF-κB [ 47 ] . To repress NF-κB, the GR associates through protein-protein interactions with NF-κB bound at κB response elements [ 44 45 46 47 ] . The precise relationship between decreased NF-κB-mediated transcription and a decreased GR protein expression is unclear.