Words similar to neurotrophins
Example sentences for: neurotrophins
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Past work has shown that BDNF and NT-3 appear to shift in their expression into inner hair cells around birth or are lost in the ear and other parts of the nervous system [ 6 10 20 23 ] . It has been suggested that other neurotrophins may come into play in the ear [ 11 ] . However, the apex of Brn3c null mutants, which retains most of the spiral neuron afferents at 6-month, shows no formation of mature hair cells at any time surveyed here (P0, P8, P10).
Most previous attempts to establish an organotypic culture model of axonal growth on CNS white matter have failed because it was not possible to obtain attachment of neurons to white matter without enzymatically altering the substrate [ 31] or treating with neurotrophins [ 31, 32] or conditioned medium [ 33].
In the ear [ 4 ] as well as elsewhere [ 10 ] neurotrophins are progressively downregulated in postnatal mammals and possibly replaced by other factors [ 11 ] .
In essence, this theory of regulation of neuronal connections via neurotrophic support implies that only limited quantities of neurotrophins are released by the target tissue to support only properly connected sensory neurons by providing only these with a critical amount of neurotrophins [ 21 ] . Past experiments, which eliminated one or more neurotrophins entirely, only partially tested the basic assumption of this theory in vivo . For example, in BDNF heterozygotic animals there is a small decrease in the number of sensory neurons in the ear [ 13 ] but no change in the overall pattern of innervation.
MX generated the null mutation, bred all the mice used for this study and generated the statistical data and the immunocytochemical data with MyoVII, AM conducted the tract tracing studies of cochlear afferents and helped with the histological analysis and assembly of image plates, UP carried out the in situ hybridization for neurotrophins and assembled the plates for these data, BF wrote the manuscript, carried out most of the neuronal tracing and immunocytochemistry for acetylated tubulin and data presentation.
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