Words similar to neurotrophins

Example sentences for: neurotrophins

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The neurotrophins play crucial functions in the interaction of muscles with their innervating neurons during development and in the adult vertebrate organism.
Past work has shown that BDNF and NT-3 appear to shift in their expression into inner hair cells around birth or are lost in the ear and other parts of the nervous system [ 6 10 20 23 ] . It has been suggested that other neurotrophins may come into play in the ear [ 11 ] . However, the apex of Brn3c null mutants, which retains most of the spiral neuron afferents at 6-month, shows no formation of mature hair cells at any time surveyed here (P0, P8, P10).
Long term survival of apical sensory neurons is unrelated to differentiated hair cells and likely is independent of neurotrophins
However, known neurotrophins are largely absent in the adult cochleae [ 4 ] and significant amounts of neurotrophin expression appear to develop only in postnatal animals in the CNS [ 24 ] . Such expression in the CNS could possibly offset to some extent the peripheral loss of neutrophins in targeted null mutants.
In the ear [ 4 ] as well as elsewhere [ 10 ] neurotrophins are progressively downregulated in postnatal mammals and possibly replaced by other factors [ 11 ] .