Words similar to neurotrophins
Example sentences for: neurotrophins
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This retention of apical spiral neurons is also largely unrelated to neurotrophins which are known to be reduced in their expression in neonatal rodents [ 4 ] .
Past work has shown that BDNF and NT-3 appear to shift in their expression into inner hair cells around birth or are lost in the ear and other parts of the nervous system [ 6 10 20 23 ] . It has been suggested that other neurotrophins may come into play in the ear [ 11 ] . However, the apex of Brn3c null mutants, which retains most of the spiral neuron afferents at 6-month, shows no formation of mature hair cells at any time surveyed here (P0, P8, P10).
MX generated the null mutation, bred all the mice used for this study and generated the statistical data and the immunocytochemical data with MyoVII, AM conducted the tract tracing studies of cochlear afferents and helped with the histological analysis and assembly of image plates, UP carried out the in situ hybridization for neurotrophins and assembled the plates for these data, BF wrote the manuscript, carried out most of the neuronal tracing and immunocytochemistry for acetylated tubulin and data presentation.
The neurotrophins have long been implicated as the mediators for target mediated cell death.
The progressive loss of afferent and efferent innervation in Brn3c null mutants shows neither in spatial nor in temporal pattern a resemblance to losses reported in simple BDNF or NT-3 null mutations [ 6 ] . Null mutants of ear specific neurotrophins have completed the loss of sensory neurons before birth.
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