Words similar to neurotrophins
Example sentences for: neurotrophins
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We processed four ears of P0 and P8 Brn3c null and control littermates for expression of BDNF and NT-3 using the riboprobes previously described [ 7 ] . We did not analyze neurotrophin expression in 6-month old animals as neurotrophins are downregulated in neonates [ 20 ] and no expression can be found even in normal animals [ 4 ] . In the canal cristae we expected, and found, only a BDNF signal.
This retention of apical spiral neurons is also largely unrelated to neurotrophins which are known to be reduced in their expression in neonatal rodents [ 4 ] .
In essence, this theory of regulation of neuronal connections via neurotrophic support implies that only limited quantities of neurotrophins are released by the target tissue to support only properly connected sensory neurons by providing only these with a critical amount of neurotrophins [ 21 ] . Past experiments, which eliminated one or more neurotrophins entirely, only partially tested the basic assumption of this theory in vivo . For example, in BDNF heterozygotic animals there is a small decrease in the number of sensory neurons in the ear [ 13 ] but no change in the overall pattern of innervation.
Thus the factor(s) cannot be released by differentiated hair cells but there is an unexplored possibility of generalized expression of neurotrophins at low levels in the undifferentiated epithelia.
Three neurotrophins, BDNF, NT-3, and NT-4/5 are known to contribute to the development, maintenance, and functioning of the neuromuscular system.
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