Example sentences for: neurotrophic

How can you use “neurotrophic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • .. ", ultimately leading to " ...expression of brain-derived neurotrophic factor (BDNF) messenger RNA " in cerebellar primary culture neurons [ 56 ] . In another study, basic fibroblast growth factor (bFGF) was shown to significantly protect cerebellar granule neurons in culture from the neurotoxicity by domoic acid, perhaps " ...through a direct interaction of bFGF and bFGF receptors on the neuronal surface.

  • In the PEDF spatial structure, the putative GAG binding domain is distinct from and non-overlapping with the neurotrophic active region [ 14 20 ] .

  • It induces neuronal differentiation in retinoblastoma cells, protects retina neurons (including photoreceptors) from death by apoptosis and other insults, and has a morphogenetic effect on photoreceptor cells [ 3 4 5 6 ] . It also has neurotrophic effects on neurons from the cerebellum, hippocampus and spinal cord [ 7 8 9 10 11 12 ] . In the intact retina, this factor is identified as a secreted protein associated by ionic interactions with the interphotoreceptor matrix [ 13 14 ] , where GAGs are the major polyanionic components.

  • Although details of the mechanism remain to be revealed, it is clear that heparin/HS is required for the first step of the neurotrophic activity of PEDF, namely the encounters with its receptor at the cell surface.

  • Specifically, efferent fibers may suffer the same loss of their molecularly unknown neurotrophic support as do afferents and therefore show the same spatio-temporal profile of loss (Fig.


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