Words similar to neurotrophic
Example sentences for: neurotrophic
How can you use “neurotrophic” in a sentence? Here are some example sentences to help you improve your vocabulary:
The injury constitutes an enormous stress to the cell and also deprives it from contact with its normal target-derived neurotrophic support.
Although details of the mechanism remain to be revealed, it is clear that heparin/HS is required for the first step of the neurotrophic activity of PEDF, namely the encounters with its receptor at the cell surface.
The ligands ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1) and a novel neurotrophin set, known alternatively as NNT-1/BSF3 and CLF/CLC, also function through the high affinity LIFR:gp130 heterodimeric receptor but require a third ligand-binding but non-signaling subunit [ 1 2 3 4 ] . Oncostatin M (OSM) utilizes LIFR:gp130 as an alternative receptor complex for OSM signaling in humans [ 5 ] , but not in mice [ 6 ] . Thus, in mice LIFR:gp130 is obligatory for signaling induced by LIF, CNTF, CT-1 and CLF/CLC.
Its neurotrophic activities are independent of its protease inhibition potential but dependent on its interaction with cell-surface receptors [ 9 12 16 17 18 ] . PEDF has high binding affinity for cell-surface receptors in human retinoblastoma Y-79 cells (K
GABA is a well-documented neurotrophic agent involved in brain development [ 27 28 29 30 ] . Most of the work done on the effects of GABA and neural development has been done on embryos and embryonic tissue well past the neural tube stage [ 27 31 32 ] . However, there is evidence of glutamic acid decarboxylase (GAD) and GABA receptor expression about the time of neural tube formation [ 27 ] . Given that GABA is important to neural development, and the early developmental time frame of the GABA system, it is logical that agents active at the GABA receptor (ethanol, BDZs) can have adverse consequences on CNS development.
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