Words similar to neurotrophic

Example sentences for: neurotrophic

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Its neurotrophic activities are independent of its protease inhibition potential but dependent on its interaction with cell-surface receptors [ 9 12 16 17 18 ] . PEDF has high binding affinity for cell-surface receptors in human retinoblastoma Y-79 cells (K
Although details of the mechanism remain to be revealed, it is clear that heparin/HS is required for the first step of the neurotrophic activity of PEDF, namely the encounters with its receptor at the cell surface.
Specifically, efferent fibers may suffer the same loss of their molecularly unknown neurotrophic support as do afferents and therefore show the same spatio-temporal profile of loss (Fig.
In essence, this theory of regulation of neuronal connections via neurotrophic support implies that only limited quantities of neurotrophins are released by the target tissue to support only properly connected sensory neurons by providing only these with a critical amount of neurotrophins [ 21 ] . Past experiments, which eliminated one or more neurotrophins entirely, only partially tested the basic assumption of this theory in vivo . For example, in BDNF heterozygotic animals there is a small decrease in the number of sensory neurons in the ear [ 13 ] but no change in the overall pattern of innervation.
It therefore remains unclear what supports the many afferents in the apex of the Brn3c null mutants until 6 months of age or longer, unknown peripheral neurotrophic substances or neurotrophic support provided by the CNS.