Words similar to neurotrophic
Example sentences for: neurotrophic
How can you use “neurotrophic” in a sentence? Here are some example sentences to help you improve your vocabulary:
It has been proposed that the GAG-binding property of PEDF provides the molecular basis for its association with extracellular matrices and may serve to localize PEDF activity in the retina and CNS [ 14 19 ] . However, the present results point to direct effects these polysaccharides might have on the biochemical interactions between PEDF and PEDF receptors on the surfaces of cells that respond to this neurotrophic factor.
It therefore remains unclear what supports the many afferents in the apex of the Brn3c null mutants until 6 months of age or longer, unknown peripheral neurotrophic substances or neurotrophic support provided by the CNS.
In essence, this theory of regulation of neuronal connections via neurotrophic support implies that only limited quantities of neurotrophins are released by the target tissue to support only properly connected sensory neurons by providing only these with a critical amount of neurotrophins [ 21 ] . Past experiments, which eliminated one or more neurotrophins entirely, only partially tested the basic assumption of this theory in vivo . For example, in BDNF heterozygotic animals there is a small decrease in the number of sensory neurons in the ear [ 13 ] but no change in the overall pattern of innervation.
In a spatial structure of PEDF, the heparin/HS binding domain of PEDF maps to the opposite side of the neurotrophic active region [ 20 ] , allowing distinct and non-overlapping interactions with heparin/HS on one side of the protein, and with the neurotrophic receptor on its opposite side.
GABA is a well-documented neurotrophic agent involved in brain development [ 27 28 29 30 ] . Most of the work done on the effects of GABA and neural development has been done on embryos and embryonic tissue well past the neural tube stage [ 27 31 32 ] . However, there is evidence of glutamic acid decarboxylase (GAD) and GABA receptor expression about the time of neural tube formation [ 27 ] . Given that GABA is important to neural development, and the early developmental time frame of the GABA system, it is logical that agents active at the GABA receptor (ethanol, BDZs) can have adverse consequences on CNS development.
Loading...