Example sentences for: neurotrophin

How can you use “neurotrophin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Moreover, all of the neurotrophin/neurotrophin receptor null mutants studied to date eliminate expression in both the peripheral target and the brain simultaneously and achieve their effects in late embryos.

  • Nerve growth factor (NGF), a prototypical neurotrophic factor and a member of the neurotrophin family, promotes a wide range of responses in its target cells.

  • The neurotrophin family includes Nerve Growth Factor (NGF), Neurotrophin-3 (NT-3), Neurotrophin-4/5 (NT-4/5), Neurotrophin-6 (NT6) and Brain-derived Neurotrophic Factor (BDNF).

  • The ligands ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1) and a novel neurotrophin set, known alternatively as NNT-1/BSF3 and CLF/CLC, also function through the high affinity LIFR:gp130 heterodimeric receptor but require a third ligand-binding but non-signaling subunit [ 1 2 3 4 ] . Oncostatin M (OSM) utilizes LIFR:gp130 as an alternative receptor complex for OSM signaling in humans [ 5 ] , but not in mice [ 6 ] . Thus, in mice LIFR:gp130 is obligatory for signaling induced by LIF, CNTF, CT-1 and CLF/CLC.

  • However, known neurotrophins are largely absent in the adult cochleae [ 4 ] and significant amounts of neurotrophin expression appear to develop only in postnatal animals in the CNS [ 24 ] . Such expression in the CNS could possibly offset to some extent the peripheral loss of neutrophins in targeted null mutants.


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