Words similar to neurotrophin
Example sentences for: neurotrophin
How can you use “neurotrophin” in a sentence? Here are some example sentences to help you improve your vocabulary:
The ligands ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1) and a novel neurotrophin set, known alternatively as NNT-1/BSF3 and CLF/CLC, also function through the high affinity LIFR:gp130 heterodimeric receptor but require a third ligand-binding but non-signaling subunit [ 1 2 3 4 ] . Oncostatin M (OSM) utilizes LIFR:gp130 as an alternative receptor complex for OSM signaling in humans [ 5 ] , but not in mice [ 6 ] . Thus, in mice LIFR:gp130 is obligatory for signaling induced by LIF, CNTF, CT-1 and CLF/CLC.
We processed four ears of P0 and P8 Brn3c null and control littermates for expression of BDNF and NT-3 using the riboprobes previously described [ 7 ] . We did not analyze neurotrophin expression in 6-month old animals as neurotrophins are downregulated in neonates [ 20 ] and no expression can be found even in normal animals [ 4 ] . In the canal cristae we expected, and found, only a BDNF signal.
However, known neurotrophins are largely absent in the adult cochleae [ 4 ] and significant amounts of neurotrophin expression appear to develop only in postnatal animals in the CNS [ 24 ] . Such expression in the CNS could possibly offset to some extent the peripheral loss of neutrophins in targeted null mutants.
Importantly, the spatio-temporal loss of innervation does not follow the pattern of loss known from neurotrophin and neurotrophin receptor null mutations as it starts in Brn3c mutant mice after birth.
This late sensory neuron loss is likely not related to known neurotrophin signaling which becomes reduced in neonatal wildtype animals.
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