Words similar to nac
Example sentences for: nac
How can you use “nac” in a sentence? Here are some example sentences to help you improve your vocabulary:
To determine whether RSV and TNFα activate NF-κB differently, we examined the effects of NAC and DEX on Rel A and p50 binding activity.
IL-8, MCP-1 and RANTES gene expression are regulated by the redox responsive transcription factor NF-κB [ 18 20 23 25 26 27 28 29 30 31 32 33 41 42 43 44 ] . The NF-κB signaling pathways have been shown to be differentially affected by antioxidants and glucocorticoid steroids [ 45 ] . To determine whether RSV and TNFα induction of chemokine expression might be mediated by different NF-κB signaling pathways we pretreated A549 cells with the glutathione precursor N-acetyl-L-cysteine (NAC) or the synthetic glucocorticoid dexamethasone (DEX).
Primer sequences are as follows: 5'-CCACTGTAGATGGGCTATGC-3' and 5'-AGGGATAACAATATCGCCAA-3' for Cab; 5'-TCACCCAAAAGAGAAGAGCA-3' and 5'-CAAAGCCATCAAGACAAACA-3' for Ltp4; 5'-TCTTATTAGCCGTGTGCCTG-3' and 5'-CAACTAGCAAACCAATGCCC-3' for Ltp6; 5'-CAACATGGGAAGCTGTTTTG-3' and 5'-CAAGCACACGTTATTTCCCC-3' for NAC1;5'-CGGAGAAGAAGAGGAGACCA-3' and 5'-GAGGGTCAAGAAGTCCAGTG-3' for PRKase; 5'-GTTCCACCTGAAGAAGCAGG-3' and 5'-CGCATAAATGGTTGGGAGTT-3' for rbcL; 5'-GAGTGGAAACGCAGGAGAAG-3' and 5'-ACTCCAAGGCTCTCAACGAA-3' for Ra; 5'-TGGTGGACTCTCCGTTCTTC-3' and 5'-CGAGTTGTGACCATAAGCCA-3' for RCP1; 5'-TCAAATCCTCGTTGACAGAC-3' and 5'-CTGTTGCCTCCATTGACAGA-3' for TIM; and 5'-CAAATGGCTCTTTCTTCACC-3' and 5'-TGGTTCTTAACTTCCGCCAC-3' for XCP2.
4, Rel A and p50 subunits are differentially inhibited by NAC and DEX which have been shown to inhibit NF-κB by distinct mechanisms.
NAC is an antioxidant thiol that raises the intracellular pool of glutathione the major redox regulating mechanism in the A549 epithelial cell line [ 45 ] . Interestingly, it has been reported that NAC can have differential effects on NF-κB binding activity suggesting only a subset of NF-κB binding complexes are redox sensitive [ 58 ] . Moreover, it has been shown that NAC inhibits Rel A/p50 heterodimers but not p50 homodimers and can inhibit NF-κB binding to only certain variant κB elements which presumably interact with distinct redox sensitive NF-κB binding complexes [ 59 ] . These observations are consistent with our findings that indicate NAC predominantly inhibits Rel A homodimers since that was the major NF-κB subunit induced by RSV infection of A549 cells.
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