Words similar to modulated
Example sentences for: modulated
How can you use “modulated” in a sentence? Here are some example sentences to help you improve your vocabulary:
For example, Herschlag and co-workers have previously shown that a nucleobase could complement an abasic site within the hammerhead ribozyme, restoring cleavage activity [ 1 ] . Similarly, Porta and Lizardi engineered a hammerhead ribozyme that assumed an inactive secondary structure; upon the addition of an oligonucleotide that disrupted the engineered secondary structure, the ribozyme was activated [ 2 ] . More recently, it has previously been shown that many selected nucleic acid binding species (aptamers) undergo conformational changes upon ligand binding [ 3 4 5 6 ] In addition, when aptamers are conjoined to ribozymes, the ligand-induced conformational changes in the aptamers frequently modulate the structures and hence the activities of the ribozymes [ 7 8 9 ] For example, binding of theophylline to the anti-theophylline aptamer [ 10 ] modulates the conformation of residue [ 11 12 ] and the overall stability of the aptamer [ 10 13 ] . Appending the anti-theophylline aptamer to the hammerhead ribozyme allowed cleavage activity to be modulated by 110-fold by theophylline [ 13 ] . Similarly, appending the anti-theophylline aptamer to a small ribozyme ligase (L1) generated an aptazyme that was activated 1,600-fold by saturating theophylline concentrations [ 14 ] .
The prostate has been the paradigm site for treatment planning efforts related to conformal therapy [ 9 10 11 12 ] and intensity modulated radiotherapy (IMRT)/inverse planning [ 13 14 ] . Also, the prostate has been the leading disease site for efforts related to improving daily setup [ 15 ] and incorporating organ motion into the delivery strategy [ 16 ] . These above efforts have allowed for dose escalation of the prostate while minimizing early and late treatment toxicity [ 9 10 11 12 13 14 17 ] .
Expression of the various isoforms during development is modulated both spatially and temporally [ 42], and observations from gene knockout studies have proven that these isoforms do not have equivalent biological functions during vessel development [ 42, 43].
Cytokines and growth factors and their receptors were a major group of IL-1-modulated genes in chondrocytes (Table 2, panel B).
Secondly, mefloquine has been shown to cause a striking upregulation of GADD153, a transcription factor selectively modulated under conditions of ER stress [ 8 ] . However, the depletion of the ER calcium pool on the one hand, and a consequent induction of an ER stress response have not been shown to occur simultaneously in intact primary neurons.
Loading...