Words similar to modulated
Example sentences for: modulated
How can you use “modulated” in a sentence? Here are some example sentences to help you improve your vocabulary:
Thus, this data point was used in a larger cohort of patients to identify genes consistently modulated by IL-2 administration.
Our results show that NOM modulated the expression of MDR1 in a time-dependent manner.
Because EGF and its receptor (EGF-R) are involved in prostate cell growth, and their expression can be modulated by androgen and RA [ 18 19 20 ] , we also examined the interaction of T and RA on the expression of EGF-R.
These areas are strongly modulated by dopamine and suggest the importance of examining genes that modulate dopamine.
For example, Herschlag and co-workers have previously shown that a nucleobase could complement an abasic site within the hammerhead ribozyme, restoring cleavage activity [ 1 ] . Similarly, Porta and Lizardi engineered a hammerhead ribozyme that assumed an inactive secondary structure; upon the addition of an oligonucleotide that disrupted the engineered secondary structure, the ribozyme was activated [ 2 ] . More recently, it has previously been shown that many selected nucleic acid binding species (aptamers) undergo conformational changes upon ligand binding [ 3 4 5 6 ] In addition, when aptamers are conjoined to ribozymes, the ligand-induced conformational changes in the aptamers frequently modulate the structures and hence the activities of the ribozymes [ 7 8 9 ] For example, binding of theophylline to the anti-theophylline aptamer [ 10 ] modulates the conformation of residue [ 11 12 ] and the overall stability of the aptamer [ 10 13 ] . Appending the anti-theophylline aptamer to the hammerhead ribozyme allowed cleavage activity to be modulated by 110-fold by theophylline [ 13 ] . Similarly, appending the anti-theophylline aptamer to a small ribozyme ligase (L1) generated an aptazyme that was activated 1,600-fold by saturating theophylline concentrations [ 14 ] .
Loading...