Example sentences for: mhc

How can you use “mhc” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Development of an efficient energy function for the accurate prediction of both backbone and side-chain conformations followed by an effective MHC-peptide interaction function will help to quantify the differences in peptide binding caused by MHC polymorphism and peptide diversity.

  • Changing the interaction of peptide, MHC class II molecules, T cell receptors and other antigen-presenting cell specific ligand interactions to foster stronger, higher affinity T cell signalling has been shown in mice to skew T cell differentiation from Th2 to Th1-like patterns [ 40 41 42 43 44 45 46 47 48 49 50 ] . Differences in Th-differentiation patterns have downstream effects on the type of immune response mounted, and in particular on the isotypes of antibody expressed.

  • Labeling with the primary antibodies took place in 0.1% gelatin-TNT buffer for 1 hour at room temperature, with the following dilutions: 1:500 of the anti-MHC antibody (Sigma, Saint Louis, MO, USA); 1:2,000 of the anti-TM antibody (Sigma, Saint Louis, MO, USA); and 1:10,000 of the anti-caldesmon (gift from Dr. L. Adam, Bristol-Myers-Squibb, USA), anti-calponin (Sigma, Saint Louis, MO, USA), anti-α-actin (Biomeda Corporation, Foster city, CA, USA) and anti-MLC20 (gift from Dr. S. Gunst, Indiana State University, USA).

  • SB = sidechain MHC - backbone peptide

  • The TNF locus (MIM *191160) has been associated with susceptibility to a wide range of infectious and inflammatory diseases, including malaria, typhoid, leishmaniasis, meningococcal sepsis, trachoma, asthma, multiple sclerosis, and inflammatory bowel disease [ 1 2 3 4 5 6 7 8 9 10 11 ] . Thus far, these associations have not been mapped in any detail, and as TNF lies in the central part of the major histocompatibility complex (MHC), there are many candidate genes that could potentially be responsible.


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