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Example sentences for: mhab

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The murinised ATF-BPTI (mhAB) plasmid was constructed by an identical procedure, using the (Tyr22, Arg27,29,30) uPA mutant cDNA as starting sequence [ 33 ] .
The results, depicted in Fig 4, show a linear dose response with a maximum level of 500-800 ng / ml obtained when 10 10iu Ad Adapt mhAB was injected intravenously.
An mhATF-BPTI enzyme-linked immunoabsorbent assay (ELISA) was developed by Dr. P. Quax (Toegepast Natuurwetenschappelijk Onderzoek institute), using a monoclonal antibody specific for the ATF as the capture antibody and a polyclonal antibody directed against BPTI as the detector antibody [ 18 ] . As a standard we used medium of Ad5 Adapt mhAB infected CHO cell culture in which the mhATF-BPTI concentration was determined by an urokinase ELISA.
The Ad Adapt mhAB encodes for a murinised form of the human ATF-BPTI [ 21 ] . In this construct the mhAB, is preceded by the native secretion signal peptide of the human urokinase.
The plasma levels of mhAB, monitored for 3 weeks after the injection, showed a peak at 10 ± 4 ng /ml on day 10 after administration.