Words similar to mirna

Example sentences for: mirna

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In this study, we describe miRseeker, a computational approach for the identification of Drosophila miRNA genes that ranks conserved stem-loop structures and assesses their pattern of nucleotide divergence.
Candidate mature miRNA sequences were defined by the bounds of the perfectly conserved sequence.
Of the reference set miRNAs, only mir-2b-1 failed these filters (as a class 6 miRNA), even though it received the eighth highest score of all super-regions in the entire euchromatic sequence of the drosophilid genomes.
We then defined a potential miRNA candidate sequence as being a perfectly conserved block of sequence greater than 22 nucleotides in length located less than 10 nucleotides from the end of the terminal loop, and eliminated those candidates that did not contain a potential miRNA (Figure 2a, class 4).
Despite these potential sources of error, the robust ability of miRseeker to identify genuine miRNAs is clearly indicated by its ability to identify most of the previously known Drosophila miRNAs as very high-scoring candidates and by our experimental validation of a very large number of newly identified candidate miRNA genes.