Words similar to mirna

Example sentences for: mirna

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Consideration of nucleotide bias at the 5' end of miRNA (including a propensity to begin with U) may improve predictions [ 11 ] , although we stress that our algorithms were designed to predict pre-miRNA genes and not mature miRNA sequences themselves.
Incorporation of promoter evidence in gene models may also help, given recent speculation that miRNA genes may be transcribed by RNA polymerase II.
The largest cluster of miRNA genes in Drosophila includes six that were previously identified as the mir-3 → mir-6-3 cluster [ 10 ] . We identified two additional conserved stem-loop structures that flank mir-3 (Figure 7a), one of which ( mir-286 ) was confirmed by northern blot (Figure 5a).
Conservation alone is an insufficient criterion for assessing the validity of a miRNA [ 46 ] . Indeed, one high-scoring candidate (number 78, 2L:13233310 that is strongly conserved in Anopheles and was identified by miRseeker appears to be an unannotated U2 snRNA [ 43 ] . Nevertheless, our high success rate (20/27) leads us to believe that failure to observe expression of a high-scoring, third-species-conserved miRseeker candidate could reflect a false-negative result.
Mutations do eventually accumulate on the non-miRNA-encoding arm, and orthologous pre-miRNAs from more diverged species will often preserve only the 21-24 nucleotide mature miRNA itself.