Words similar to mirna
Example sentences for: mirna
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Mutations do eventually accumulate on the non-miRNA-encoding arm, and orthologous pre-miRNAs from more diverged species will often preserve only the 21-24 nucleotide mature miRNA itself.
As a complementary approach to miRNA identification, we developed an informatic strategy ('miRseeker') and applied it to the completed genomes of Drosophila melanogaster and D. pseudoobscura , which are some 30 million years diverged.
When viewed in VISTA plot alignments [ 35 ] , miRNA genes reside in short regions of exceptional conservation, easily seen as local 'peaks' (Figure 1).
The largest cluster of miRNA genes in Drosophila includes six that were previously identified as the mir-3 → mir-6-3 cluster [ 10 ] . We identified two additional conserved stem-loop structures that flank mir-3 (Figure 7a), one of which ( mir-286 ) was confirmed by northern blot (Figure 5a).
Our data allows us to estimate the presence of around 110 miRNA genes in Drosophila . The approach used in this study should be applicable to the analysis of other sets of sequenced genomes of related higher eukaryotic model organisms.