Words similar to mirna

Example sentences for: mirna

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Of the reference set miRNAs, only mir-2b-1 failed these filters (as a class 6 miRNA), even though it received the eighth highest score of all super-regions in the entire euchromatic sequence of the drosophilid genomes.
The starting point for our studies was a reference set of 24 Drosophila pre-miRNA sequences ( let-7 , the 21 originally identified by Lagos-Quintana and colleagues, mir-125 , and a previously undescribed paralog of mir-2 that we named mir-2c [ 9 10 29 ] ). We analyzed this set to derive rules and determine parameters that specifically describe known miRNA genes within anonymous genomic sequence.
However, pilot studies identified a very large number of conserved stem-loops in genomic sequence, suggesting that additional criteria were necessary to make effective miRNA gene predictions.
In theory, a computational approach based on the structural features of known miRNA genes might permit the unbiased discovery of the remaining complement of miRNA genes in a given sequenced genome.
While this manuscript was in preparation and in submission, several other computational predictions of miRNA genes by similar overall strategies were reported [ 31 32 33 34 ] . The results of our studies are most similar to analyses by Bartel and colleagues predicting 200-255 miRNA genes in vertebrates, or nearly 1% of the predicted genes in humans [ 31 ] ; this is comparable to our estimate of flies.