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Example sentences for: mirnas

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However, because of preferential divergence within the loop, orthologous miRNAs from species of an appropriate evolutionary distance (such as D. melanogaster and D. pseudoobscura ) show an equal or greater amount of change within the loop than on the non-miRNA-encoding arm (Figure 2a, class 3).
In many cases, miRNAs effect silencing by basepairing to the 3′ ends of target mRNAs and repressing translation (see Figure 1).
We eliminated those that contained more than four additional non-conserved positions in the non-miRNA-encoding arm compared to within the loop (Figure 2a, class 6), leaving behind class 3 candidates as potential miRNAs.
As an example, we show alignments and RNA folds of the four insect orthologs of 2R:11128979, which all adopt canonical, high-scoring stem-loop structures and collectively display patterns of nucleotide divergence characteristic of genuine miRNAs (preponderance of divergence within the loop, slightly less divergence along a nonconserved arm, and perfect conservation of a putative miRNA-encoding arm) (Figure 6).
Therefore, we estimate 72-93 miRNAs (18 reference + 25 novel verified genes + 29-50 additional unverified candidates) at a cutoff that includes 18/24 (75%) members of the reference set, allowing us to extrapolate that drosophilid genomes may contain 96-124, or around 110 miRNA genes.