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Example sentences for: mirnas
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Selected hybridizations that illustrate the different temporal and quantitative profiles are shown in Figure 5and the collected northern data are summarized in Table 2. We also note that these experimentally verified miRNAs vary tremendously in abundance, with several being two to three orders of magnitude less abundant than miRNAs discovered by direct cloning.
In addition, a subset of the newly identified miRNAs (miR-34, miR-79, miR-87, miR-92a, miR-124b, miR-133 and miR-263a) were independently found by homology search or by informatic means and confirmed by northern analysis while this work was under review [ 34 45 ] .
Up until 2002, RNAi/PTGS and miRNAs were the most avidly studied aspects of RNA-mediated gene silencing.
The 5' ends of a large subset of experimentally derived Drosophila miRNAs were recently observed to be perfectly complementary to Brd boxes, K boxes and GY boxes, a set of 3' UTR sequence motifs involved in post-transcriptional regulation [ 47 53 54 55 ] . This suggests that, at least in Drosophila , a subset of relevant miRNA targets might be found by searching for complements to the 5'-most 8-10 nucleotides of miRNAs in 3' UTRs.
The proof of principle behind this dual scheme was demonstrated by the identification of several miRNAs via a structural analysis of genomic sequence conserved over 50 million years of nematode evolution [ 12 ] . Indeed, the great majority of C. elegans miRNAs identified through the direct cloning approach are conserved in the genome of C. briggsae , with conservation typically extending across the length of the predicted miRNA precursor.
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