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Example sentences for: mirnas
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The proof of principle behind this dual scheme was demonstrated by the identification of several miRNAs via a structural analysis of genomic sequence conserved over 50 million years of nematode evolution [ 12 ] . Indeed, the great majority of C. elegans miRNAs identified through the direct cloning approach are conserved in the genome of C. briggsae , with conservation typically extending across the length of the predicted miRNA precursor.
A progressively increasing penalty was applied for symmetric loops greater than three nucleotides as well as for all bulged nucleotides and asymmetrically sized loops, as these are more rarely observed in genuine miRNAs.
We next sought to validate the predicted miRNAs by northern blot of total RNA isolated from 0-24 hour embryos, third instar larvae and early pupae, and adult males.
While this work was under review, the clustering of miR-100, let-7 and miR-125 was independently reported; these researchers also provide evidence for coordinate expression of these miRNAs as a single pri-miRNA [ 45 50 ] .
Although complementary sites for both miRNAs are found in the 3' UTRs of several putative nematode targets, these miRNAs are not physically linked in the C. elegans genome and their mutant phenotypes are principally due to misregulation of different transcripts [ 4 5 6 8 ] . The function of these miRNAs has not yet been explicitly demonstrated in other species, but Drosophila let-7 is regulated at the larval-pupal transition by ecdysone [ 49 ] , and all three members of this cluster are present in other insects and in vertebrates, thus implying broadly conserved functions.
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