Words similar to mirnas
Example sentences for: mirnas
How can you use “mirnas” in a sentence? Here are some example sentences to help you improve your vocabulary:
However, in one test, around 5% of randomly selected C. elegans genomic sequences were found to have the capacity to fold into plausible miRNA precursor hairpins [ 11 ] . This suggests that computational prediction of miRNAs based on presumed structure alone would have an unacceptably high false-positive rate.
Although complementary sites for both miRNAs are found in the 3' UTRs of several putative nematode targets, these miRNAs are not physically linked in the C. elegans genome and their mutant phenotypes are principally due to misregulation of different transcripts [ 4 5 6 8 ] . The function of these miRNAs has not yet been explicitly demonstrated in other species, but Drosophila let-7 is regulated at the larval-pupal transition by ecdysone [ 49 ] , and all three members of this cluster are present in other insects and in vertebrates, thus implying broadly conserved functions.
Therefore, we estimate 72-93 miRNAs (18 reference + 25 novel verified genes + 29-50 additional unverified candidates) at a cutoff that includes 18/24 (75%) members of the reference set, allowing us to extrapolate that drosophilid genomes may contain 96-124, or around 110 miRNA genes.
We took care to verify that our windowing parameters segregated individual miRNAs within known miRNA clusters (the mir-2 , mir-13 and mir-3 → mir-6 clusters [ 10 ] ) into distinct super-regions.
However, because of preferential divergence within the loop, orthologous miRNAs from species of an appropriate evolutionary distance (such as D. melanogaster and D. pseudoobscura ) show an equal or greater amount of change within the loop than on the non-miRNA-encoding arm (Figure 2a, class 3).
Loading...