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Example sentences for: mirnas
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The extent of the precisely conserved arm (thus including a potential miRNA) was in most cases longer than the mature product, and it would have been arbitrary to select a candidate miRNA sequence just so that it began with a U. Notably, a recent study suggests that different chemical strategies for capturing miRNA molecules may differentially recover miRNAs according to their 5' ends [ 33 ] , so reevaluation of miRNA 5' bias may be in order.
However, because of preferential divergence within the loop, orthologous miRNAs from species of an appropriate evolutionary distance (such as D. melanogaster and D. pseudoobscura ) show an equal or greater amount of change within the loop than on the non-miRNA-encoding arm (Figure 2a, class 3).
As an example, we show alignments and RNA folds of the four insect orthologs of 2R:11128979, which all adopt canonical, high-scoring stem-loop structures and collectively display patterns of nucleotide divergence characteristic of genuine miRNAs (preponderance of divergence within the loop, slightly less divergence along a nonconserved arm, and perfect conservation of a putative miRNA-encoding arm) (Figure 6).
Up until 2002, RNAi/PTGS and miRNAs were the most avidly studied aspects of RNA-mediated gene silencing.
Selected hybridizations that illustrate the different temporal and quantitative profiles are shown in Figure 5and the collected northern data are summarized in Table 2. We also note that these experimentally verified miRNAs vary tremendously in abundance, with several being two to three orders of magnitude less abundant than miRNAs discovered by direct cloning.
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