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Example sentences for: mirnas

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As an example, we show alignments and RNA folds of the four insect orthologs of 2R:11128979, which all adopt canonical, high-scoring stem-loop structures and collectively display patterns of nucleotide divergence characteristic of genuine miRNAs (preponderance of divergence within the loop, slightly less divergence along a nonconserved arm, and perfect conservation of a putative miRNA-encoding arm) (Figure 6).
For example, 41% of miRNAs cloned from HeLa cells are variants of let-7, 28% of human brain miRNAs are variants of miR-124, and 45% of miRNAs cloned from human heart and 32% of those cloned from early Drosophila embryos are miR-1 [ 10 29 ] . In fact, it has been opined that few additional mammalian miRNAs will be easily identified by the direct cloning method [ 30 ] .
Since unpaired nucleotides in known miRNAs have a tendency to be found in symmetric loops, the presence of asymmetric loops and bulged nucleotides was further penalized.
We propose then that classes 1-3 represent the normal pattern of evolutionary divergence of miRNAs, and consider Drosophila candidates that fall into these classes to represent 'good' miRNA candidates.
We identified several additional examples of closely linked miRNAs that are transcribed from the same strand (Figure 7d).