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Example sentences for: mirnas

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Since unpaired nucleotides in known miRNAs have a tendency to be found in symmetric loops, the presence of asymmetric loops and bulged nucleotides was further penalized.
The 5' ends of a large subset of experimentally derived Drosophila miRNAs were recently observed to be perfectly complementary to Brd boxes, K boxes and GY boxes, a set of 3' UTR sequence motifs involved in post-transcriptional regulation [ 47 53 54 55 ] . This suggests that, at least in Drosophila , a subset of relevant miRNA targets might be found by searching for complements to the 5'-most 8-10 nucleotides of miRNAs in 3' UTRs.
It is worth noting that the fraction of miRNAs conserved between mammals and fish, which are around 450 million years diverged, appears to be significantly higher than the fraction of miRNAs that are conserved between flies and mosquitoes, which are separated by only 250 million years of evolution (this paper and [ 31 ] ). This indicates that insect miRNAs evolve much more rapidly than do vertebrate miRNAs.
In cases where candidate miRNAs were identifiable in non-insect species, a putative 21-24 nucleotide product was usually evident.
We eliminated those that contained more than four additional non-conserved positions in the non-miRNA-encoding arm compared to within the loop (Figure 2a, class 6), leaving behind class 3 candidates as potential miRNAs.