Words similar to mirseeker
Example sentences for: mirseeker
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The first 208 candidates produced by miRseeker, along with information on structures, scores, alignments, and genomic locations, are accessible via the web [ 43 ] .
A total of 42 novel candidates in the top 208 miRseeker predictions were supported by additional evidence of sequence and structural conservation in a third species (primarily Anopheles and Apis , with a smaller fraction in nematodes or vertebrates).
In this study, we describe miRseeker, a computational approach for the identification of Drosophila miRNA genes that ranks conserved stem-loop structures and assesses their pattern of nucleotide divergence.
Unexpectedly, the Anopheles genome contains only four members of this subfamily, and all are located in a single cluster on 2L (Figure 7b); the same four members were identifiable in the unassembled genomic sequence of Apis [ 48 ] . The simplest scenario is that members of the K box-family have undergone radical duplication and dispersal about the genome in Drosophila . This is consistent with the finding that the remaining members of the K-box family [ 47 ] , including mir-11 , the three mir-6 paralogs and the K-box-antisense gene mir-5 , are similarly absent from both Anopheles and Apis . However, one new putative member of the K-box family (2R:4681879) was identified by miRseeker, and it has been conserved in all four sequenced insect genomes.
miRseeker successfully identified nearly all of the known Drosophila miRNA genes, and a strong majority of novel, high-scoring candidates were verified by northern analysis.
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