Words similar to mir-
Example sentences for: mir-
How can you use “mir-” in a sentence? Here are some example sentences to help you improve your vocabulary:
The starting point for our studies was a reference set of 24 Drosophila pre-miRNA sequences ( let-7 , the 21 originally identified by Lagos-Quintana and colleagues, mir-125 , and a previously undescribed paralog of mir-2 that we named mir-2c [ 9 10 29 ] ). We analyzed this set to derive rules and determine parameters that specifically describe known miRNA genes within anonymous genomic sequence.
While this work was under review, the clustering of miR-100, let-7 and miR-125 was independently reported; these researchers also provide evidence for coordinate expression of these miRNAs as a single pri-miRNA [ 45 50 ] .
Of the eleven members of the reference set that show divergence on both an arm and the loop, seven show more changes in the loop than on the non-miRNA-encoding arm and three have an equal number of changes on the loop and non-miRNA-encoding arm (Figure 2a, class 3); only one member of the reference set (miR-2b-1) shows a greater number of changes on the non-miRNA arm than the loop (Figure 2a, class 6).
Although most known pre-miRNAs in Drosophila , Caenorhabditis , mice and humans form relatively canonical stem-loops of around 70 to 100 nucleotides in length, plant miRNA precursors are often processed through exceptionally long stem-loops (many 150 nucleotides or longer) [ 14 15 16 ] . miR-125 is a member of the Drosophila reference set that received a low score by our informatic procedure, possibly because it may derive from an unusually long stem-loop (120 nucleotides), only a portion of which was included in the queried window.
Two of the former class were low-scoring candidates that were nonetheless conserved in Anopheles (miR-287 and miR-288), indicating that third-species conservation is in our hands a very strong indicator of a candidate gene's validity.
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