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Example sentences for: mir-
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Unexpectedly, the Anopheles genome contains only four members of this subfamily, and all are located in a single cluster on 2L (Figure 7b); the same four members were identifiable in the unassembled genomic sequence of Apis [ 48 ] . The simplest scenario is that members of the K box-family have undergone radical duplication and dispersal about the genome in Drosophila . This is consistent with the finding that the remaining members of the K-box family [ 47 ] , including mir-11 , the three mir-6 paralogs and the K-box-antisense gene mir-5 , are similarly absent from both Anopheles and Apis . However, one new putative member of the K-box family (2R:4681879) was identified by miRseeker, and it has been conserved in all four sequenced insect genomes.
The volatility of miRNA genes is further indicated by members of the miR-2/miR-13 K box subfamily [ 47 ] . Seven members were previously reported that are scattered in four genomic locations on three different chromosome arms, including a cluster of three mir-2 genes on 2L and a cluster of two mir-13 genes on 3R; we also identified an additional paralog of mir-2 ( mir-2c ) that is located in the mir-13 cluster.
We also observed that miR-286 is related at its 5' end to another experimentally verified miRNA (miR-279, Figure 5h), suggesting that they may have related functions.
In addition, a subset of the newly identified miRNAs (miR-34, miR-79, miR-87, miR-92a, miR-124b, miR-133 and miR-263a) were independently found by homology search or by informatic means and confirmed by northern analysis while this work was under review [ 34 45 ] .
The largest cluster of miRNA genes in Drosophila includes six that were previously identified as the mir-3 → mir-6-3 cluster [ 10 ] . We identified two additional conserved stem-loop structures that flank mir-3 (Figure 7a), one of which ( mir-286 ) was confirmed by northern blot (Figure 5a).
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