Words similar to mir-
Example sentences for: mir-
How can you use “mir-” in a sentence? Here are some example sentences to help you improve your vocabulary:
The starting point for our studies was a reference set of 24 Drosophila pre-miRNA sequences ( let-7 , the 21 originally identified by Lagos-Quintana and colleagues, mir-125 , and a previously undescribed paralog of mir-2 that we named mir-2c [ 9 10 29 ] ). We analyzed this set to derive rules and determine parameters that specifically describe known miRNA genes within anonymous genomic sequence.
Therefore, the identification of miR-100 in flies relied upon its conservation in other species.
This could explain why individual let-7 or miR-125 mutants with strong developmental defects have not yet been identified in Drosophila by genetic means.
Unexpectedly, the Anopheles genome contains only four members of this subfamily, and all are located in a single cluster on 2L (Figure 7b); the same four members were identifiable in the unassembled genomic sequence of Apis [ 48 ] . The simplest scenario is that members of the K box-family have undergone radical duplication and dispersal about the genome in Drosophila . This is consistent with the finding that the remaining members of the K-box family [ 47 ] , including mir-11 , the three mir-6 paralogs and the K-box-antisense gene mir-5 , are similarly absent from both Anopheles and Apis . However, one new putative member of the K-box family (2R:4681879) was identified by miRseeker, and it has been conserved in all four sequenced insect genomes.
This contrasts with observations of miRNAs in vertebrates, where the majority of known miRNAs are members of paralogous gene sets [ 31 ] . The most extreme examples of this disparity are let-7 and mir-29 , which are present in single copies in Drosophila , but are represented by thirteen and six distinct human homologs, respectively.