Words similar to mglur-mediated

Example sentences for: mglur-mediated

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Sympathetic neurons from the rat SCG that were made to express Siah1a with a group I mGluR attenuated mGluR-mediated calcium current modulation.
If the results presented here can be exprapolated to physiological situations that involve group I mGluRs, Siah1a expression in the mammalian nervous system could potentially play a role in cell excitability by influencing mGluR-mediated potassium current modulation (of M-type currents and perhaps of GIRK currents), and synaptic plasticity due to the role that group I mGluRs play in these processes [ 2 5 38 ] .
However, CaM can also interact with group III mGluRs [ 26 28 ] . Recent data suggests that the association of CaM with group III mGluRs is necessary for normal G protein activation [ 27 ] . By analogy to group III mGluRs, the ability of Siah1a to compete with CaM for binding to group I mGluRs was considered a potential mechanism for the actions of Siah1a on group I mGluR-mediated calcium current inhibition.
Therefore, a ubiquitin-deficient Siah1a construct that can bind mGluRs is capable of producing a similar reduction in mGluR-mediated calcium current modulation as the full length Siah1a.
Siah1a has been shown to be a member of the ubiquitin family of proteins involved in protein degradation through the proteasome [ 30 31 33 ] . Therefore, group I mGluR degradation was considered a potential mechanism for the decrease in mGluR-mediated calcium current modulation observed in SCG neurons.