Words similar to mhb-egf

Example sentences for: mhb-egf

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These are reasonable functions for the role of the proposed mHB-EGF :LTBP-3 protein:protein interactions as the expression of both mHB-EGF and TGF-β is important during extracellular matrix formation in wound healing [ 1 25 ] ; it has been suggested that the coordinated activities of HB-EGF and TGF-β regulate the wound healing process [ 16 ] .
Possible functions for the apparent interaction of mHB-EGF with LTBP-3 include the targeting of the TGF-β within its protective large latent complex to its appropriate TGF-β cell-surface receptor, or the targeting of the TGF-β large latent complex to the EGF receptor via binding of mHB-EGF to the appropriate EGF receptor.
As explained above, mHB-EGF has been reported to be involved as a structural protein in such tissue developmental processes as wound healing and it is feasible that the direct physical association of mHB-EGF with fibulin-1 may be useful in the tissue remodeling of a wound site and in scar formation.
It may be that LTBP-3 provides a physical link between soluble mHB-EGF and TGF-β.
Fibulin-1 may serve to anchor the mHB-EGF to its fibers as it migrates through the extracellular matrix.