Words similar to mglur

Example sentences for: mglur

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Next, when CaM was coexpressed with mGluR5b and Siah1a, calcium current modulation was significantly increased (over that in cells expressing mGluR5b and Siah1a) to 25 ± 5% (n = 12; figure 6).
Under low Ca 2+-buffering conditions, calcium current inhibition in control (mGluR5b alone) was 25 ± 4% (n = 9).
The latter hypothesis predicts a reduction in mGluR cell surface expression or perhaps a change in surface distribution in the presence of Siah1a, such as occurs in the presence of Homer proteins [ 24 44 45 ] . To test whether Siah1a expression altered the surface expression of group I mGluRs, the surface distribution of mGluR5a-myc was examined in the absence and presence of Siah1a.
For example, group I and group III mGluRs are both known to bind Calmodulin (CaM) [ 25 26 ] . In the case of group III mGluRs, the interaction with CaM is important in regulating the efficacy of G protein activation [ 27 28 ] . CaM binding to both group I and group III mGluRs can be inhibited by serine/threonine phosphorylation at specific sites [ 25 28 ] . Therefore, it is of interest in terms of mGluR function and localization to understand the roles of proteins which interact with these receptors.
Finally, coexpression of CaM reversed the effect of Siah1a on mGluR5b, indicating that the interaction of CaM and Siah1a in binding to group I mGluRs plays a novel and important role in mGluR function.