Example sentences for: mglur

How can you use “mglur” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The triple pulse voltage protocol [ 39 ] was used as the standard test pulse to assess calcium current magnitude and voltage dependence of inhibition [ 38 40 ] . Figure 1Aillustrates sample current traces from before ("con") and during inhibition by glutamate ("Glu"), in an mGluR5b-expressing cell.

  • These data also suggest that Siah1a is acting at the level of the receptor, since much of the calcium current modulation through group I mGluRs proceeds through a Gβγ-mediated pathway similar to that used by α 2 adrenergic receptors and mGluR2 [ 38 40 ] .

  • Further, a mutant of Siah1a was constructed with the RING finger domain deleted, such that the protein was unable to act in the ubiquitin/proteasome pathway [ 46 ] . This deletion construct was as effective in attenuating group I mGluR function as the wild type Siah1a, providing supporting evidence that the effect of Siah1a resulted from its physical association with the receptors, rather than through a resulting reduction in receptor expression levels.

  • As with mGluR5b, mGluR5a produced a rapid and reversible calcium current inhibition when 100 μM glutamate was applied to the bath (figure 4B).

  • To detect surface expression of the mGluR5a-myc construct, a cy3-conjugated, mouse anti-myc antibody (Sigma) was applied to live cells at room temperature for 20 minutes at a 1:150 dilution.


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