Example sentences for: mcul

How can you use “mcul” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • When mCul1 is overexpressed, a small fraction of S phase cells (3% of 800 BrdU positive cells from 6 independent wing discs) contains detectable amounts of E2F (fig.

  • To explore potential roles for Cul1 in cell cycle control in D. melanogaster , we overexpressed mouse Cul1 (mCul1) in the wing imaginal disc.

  • While the basis for the dominant negative effect of mCul1 remains unknown, it is important to recognize that inactivation of the endogenous Cul1 is incomplete so that a reduced level of Cul1 activity persists.

  • mCul1-induced apoptosis was insensitive to the coexpression of dominant negative forms of p53 (not shown).

  • The essentially complete suppression of the mCul1 phenotype by reduction of the genetic dose of E2F suggests a remarkable level of specificity, in which, among the many targets of Cul1 action, the destruction of E2F appears to be particularly important.


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