Words similar to mglurs
Example sentences for: mglurs
How can you use “mglurs” in a sentence? Here are some example sentences to help you improve your vocabulary:
The data imply two possible mechanisms for the effect of Siah1a on mGluR signaling: First, CaM association with group I mGluRs increases G protein coupling (or perhaps is required, as may be the case with group III mGluRs).
Coexpression of Siah1a with group I mGluRs
This is possible since both Siah1a binding and G protein activation have been attributed to areas on the C-terminus of group I mGluRs [ 36 42 43 ] . Alternatively, Siah1a binding may alter the 'normal' interactions of the receptors with scaffolding proteins or may cause the receptors to be targeted for degradation in the proteasome, effectively reducing the number of receptors that are 'correctly' assembled, or the number of functional receptors at the membrane.
If the results presented here can be exprapolated to physiological situations that involve group I mGluRs, Siah1a expression in the mammalian nervous system could potentially play a role in cell excitability by influencing mGluR-mediated potassium current modulation (of M-type currents and perhaps of GIRK currents), and synaptic plasticity due to the role that group I mGluRs play in these processes [ 2 5 38 ] .
For example, group I and group III mGluRs are both known to bind Calmodulin (CaM) [ 25 26 ] . In the case of group III mGluRs, the interaction with CaM is important in regulating the efficacy of G protein activation [ 27 28 ] . CaM binding to both group I and group III mGluRs can be inhibited by serine/threonine phosphorylation at specific sites [ 25 28 ] . Therefore, it is of interest in terms of mGluR function and localization to understand the roles of proteins which interact with these receptors.
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