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Example sentences for: mglurs

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These data also suggest that Siah1a is acting at the level of the receptor, since much of the calcium current modulation through group I mGluRs proceeds through a Gβγ-mediated pathway similar to that used by α 2 adrenergic receptors and mGluR2 [ 38 40 ] .
Together, these data demonstrate that in the presence of Siah1a, the function of group I mGluRs is selectively inhibited.
This is possible since both Siah1a binding and G protein activation have been attributed to areas on the C-terminus of group I mGluRs [ 36 42 43 ] . Alternatively, Siah1a binding may alter the 'normal' interactions of the receptors with scaffolding proteins or may cause the receptors to be targeted for degradation in the proteasome, effectively reducing the number of receptors that are 'correctly' assembled, or the number of functional receptors at the membrane.
Nonetheless, the data presented here suggest a novel role for Siah1a and CaM in regulating the function of group I mGluRs.
However, CaM can also interact with group III mGluRs [ 26 28 ] . Recent data suggests that the association of CaM with group III mGluRs is necessary for normal G protein activation [ 27 ] . By analogy to group III mGluRs, the ability of Siah1a to compete with CaM for binding to group I mGluRs was considered a potential mechanism for the actions of Siah1a on group I mGluR-mediated calcium current inhibition.