Words similar to mglurs

Example sentences for: mglurs

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For example, group I and group III mGluRs are both known to bind Calmodulin (CaM) [ 25 26 ] . In the case of group III mGluRs, the interaction with CaM is important in regulating the efficacy of G protein activation [ 27 28 ] . CaM binding to both group I and group III mGluRs can be inhibited by serine/threonine phosphorylation at specific sites [ 25 28 ] . Therefore, it is of interest in terms of mGluR function and localization to understand the roles of proteins which interact with these receptors.
For example, binding of Siah1a to the C-terminus of group I mGluRs may occlude the region or regions responsible for G protein activation.
The latter hypothesis predicts a reduction in mGluR cell surface expression or perhaps a change in surface distribution in the presence of Siah1a, such as occurs in the presence of Homer proteins [ 24 44 45 ] . To test whether Siah1a expression altered the surface expression of group I mGluRs, the surface distribution of mGluR5a-myc was examined in the absence and presence of Siah1a.
Finally, CaM binding to the mGluRs did not appear to be Ca 2+-dependent.
This suggests that the effect of Siah1a on group I mGluRs is a result of its physical association with the receptor, rather than a change in receptor levels.