Example sentences for: mglurs

How can you use “mglurs” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In addition to group I mGluRs, mGluR2 (a group II mGluR) was also examined.

  • These data also suggest that Siah1a is acting at the level of the receptor, since much of the calcium current modulation through group I mGluRs proceeds through a Gβγ-mediated pathway similar to that used by α 2 adrenergic receptors and mGluR2 [ 38 40 ] .

  • However, CaM can also interact with group III mGluRs [ 26 28 ] . Recent data suggests that the association of CaM with group III mGluRs is necessary for normal G protein activation [ 27 ] . By analogy to group III mGluRs, the ability of Siah1a to compete with CaM for binding to group I mGluRs was considered a potential mechanism for the actions of Siah1a on group I mGluR-mediated calcium current inhibition.

  • Finally, coexpression of CaM reversed the effect of Siah1a on mGluR5b, indicating that the interaction of CaM and Siah1a in binding to group I mGluRs plays a novel and important role in mGluR function.

  • If the results presented here can be exprapolated to physiological situations that involve group I mGluRs, Siah1a expression in the mammalian nervous system could potentially play a role in cell excitability by influencing mGluR-mediated potassium current modulation (of M-type currents and perhaps of GIRK currents), and synaptic plasticity due to the role that group I mGluRs play in these processes [ 2 5 38 ] .


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