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Example sentences for: mglurs

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These data also suggest that Siah1a is acting at the level of the receptor, since much of the calcium current modulation through group I mGluRs proceeds through a Gβγ-mediated pathway similar to that used by α 2 adrenergic receptors and mGluR2 [ 38 40 ] .
Further studies will be needed to determine if group I mGluRs and Siah1a interact physiologically, and whether this interaction has functional consequences.
Calmodulin (CaM), a calcium binding protein intricately involved in intracellular signaling, interacts with the C-terminal tail of group I mGluRs [ 25 ] . This interaction appears to be dynamically regulated.
However, CaM can also interact with group III mGluRs [ 26 28 ] . Recent data suggests that the association of CaM with group III mGluRs is necessary for normal G protein activation [ 27 ] . By analogy to group III mGluRs, the ability of Siah1a to compete with CaM for binding to group I mGluRs was considered a potential mechanism for the actions of Siah1a on group I mGluR-mediated calcium current inhibition.
This reduction of modulation by glutamate appeared to be specific for mGluRs, as NE-mediated calcium current inhibition was unaltered (figure ID).