Words similar to mglurs
Example sentences for: mglurs
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However, Siah1a had no detectable effect on mGluR2-mediated calcium current inhibition, consistent with reports demonstrating that Siah1a does not bind to group II mGluRs [ 36 ] . Cells expressing mGluR2 alone exhibited 57 ± 5% inhibition of calcium current in response to glutamate (n = 6), while those coexpressing Siah1a were inhibited 61 ± 2% (n = 6; figure 2).
Finally, CaM binding to the mGluRs did not appear to be Ca 2+-dependent.
For example, group I and group III mGluRs are both known to bind Calmodulin (CaM) [ 25 26 ] . In the case of group III mGluRs, the interaction with CaM is important in regulating the efficacy of G protein activation [ 27 28 ] . CaM binding to both group I and group III mGluRs can be inhibited by serine/threonine phosphorylation at specific sites [ 25 28 ] . Therefore, it is of interest in terms of mGluR function and localization to understand the roles of proteins which interact with these receptors.
Calmodulin (CaM), a calcium binding protein intricately involved in intracellular signaling, interacts with the C-terminal tail of group I mGluRs [ 25 ] . This interaction appears to be dynamically regulated.
These proteins have been implicated in many processes including cancer [ 33 ] , apoptosis [ 34 ] and cell cycle regulation [ 35 ] . More recently, an interaction between Siah1a and the C-terminal tail of group I mGluRs was demonstrated [ 36 ] . This interaction was specific for group I mGluRs, as it was not observed in the analogous sequences from group II (mGluR2) or group III (mGluR7) receptors.
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