Example sentences for: methylation

How can you use “methylation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • CDH1 gene by promoter methylation plays a major role in CC tumorigenesis.

  • MGMT gene encodes O(6)-methylguanine-DNA methyltransferase and this enzyme effectively removes DNA adducts formed by alkylating agents [ 33 ] . Epigenetic gene silencing of MGMT confers enhanced sensitivity to alkylating-based chemotherapy, and lack of methylation associates with failure to respond to chemotherapy [ 34 35 ] . On the contrary, all patients that had MGMT promoter methylation were dead within 21 months of initial diagnosis, which predicts a poor prognosis.

  • To examine the biological role of promoter hypermethylation in GCT, we assessed the levels of gene expression by semi-quantitative RT-PCR in 23 tumors (15 NSGCTs and 8 SGCTs) with known methylation status.

  • Thus, our results suggest that loss of expression occurs in CC cell lines by mechanism other than complete promoter methylation.

  • CDH1 is the most commonly methylated gene in the present study showing promoter methylation in 51.


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