Example sentences for: methylation

How can you use “methylation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We first assessed associations between presence of promoter methylation for each gene and various clinical, demographic, and genetic characteristics using Chi-Square test [ 55 ] and Fisher's Exact test (for small cell counts) [ 56 ] . Characteristics that we examined included: histology, stage, tumor size, patient's age, clinical outcome, treatment response, HPV type, and microsatellite instability.

  • PTGS and trans-silencing are similarly intertwined in other cases, for example in the epimutable petunia CHS41 locus [ 10 ] . PTGS often leads to DNA methylation, although primarily in coding regions [ 35 ] . However, DNA methylation of promoters, more easily aligned with transcriptional silencing, can be RNA mediated if suitable double stranded RNA versions of the promoter sequence are transcribed, either fortuitously or by design [ 36 37 38 39 40 ] . Therefore, there may be a natural tendency for PTGS loci to mature to TGS and associated trans-silencing, which in turn could prove problematic in applying PTGS in commercial plant breeding programs.

  • No significant differences in the overall promoter methylation were found in patients with complete remission (CR) compared to patients who DOC or had only partial response (PR).

  • Type of HPV infection had no association with the status of promoter methylation (Table 2).

  • The BRCA1 gene showed promoter methylation in 2 of 5 cell lines.


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