Example sentences for: methylated

How can you use “methylated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • CDH1 is the most commonly methylated gene in the present study showing promoter methylation in 51.

  • However, methylation of 3 genes did suggest a doubling ( RASSF1A and MGMT ) or tripling ( BRCA1 ) of risk compared to those who did not have these genes methylated.

  • The number of differentially regulated genes identified by these criteria, 49 with increased and 21 with decreased expression, is significantly higher than expected by random chance, but it is much lower than one would expect if MeCP2 had a crucial role as transcriptional repressor of all genes with methylated promoters.

  • This was most evident for the RARB gene, where all five cell lines showed reactivation whether or not the promoter was methylated.

  • Of these, 15 genes ( MGMT , RASSF1A , APC , RARB , CDH1 , MLH1 , TIMP3 , GSTP1 , DAPK , CDKN2A , p14 ARF , BRCA1 , FHIT , TP73 , and HIC1 ) had previously been shown to be commonly methylated in various solid tumor types [ 4 ] . Six additional genes ( RB1 , NME1 , NME2 , BTG1 , NEDD1 , and APAF1 ) were studied because of their possible involvement in genetic alterations in GCT as indicated by LOH studies [ 8 9 10 ] . The RB1 gene at 13q14.


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