Words similar to methylenetetrahydrofolate
Example sentences for: methylenetetrahydrofolate
How can you use “methylenetetrahydrofolate” in a sentence? Here are some example sentences to help you improve your vocabulary:
The canonical thymidylate synthase (TS), such as the E. coli ThyA, is a protein with a distinct α/β-fold that transfers a methyl group to dUMP from 5,10-methylenetetrahydrofolate [ 29].
The molecular basis of inherited thrombophilia now includes mutations in the genes for Factor V, prothrombin, methylenetetrahydrofolate reductase (MTHFR) and several others [ 15 ] , in addition to those encoding proteins such as antithrombin, protein C, and protein S whose role in the homeostasis between procoagulant and anticoagulant activities in the circulation is well established.
The most important of these are the aldose reductase gene ( ALR2 ) [ 17], the insertion/deletion (I/D) polymorphism of the angiotensin I - converting enzyme ( ACE ) gene [ 18, 19], C825T polymorphism of the gene encoding the beta-3 subunit of geterotrimeric G-proteins ( GNB3 ) [ 20, 21, 22], and C677T polymorphism of the methylenetetrahydrofolate reductase gene ( MTHFR ) [ 23].
However, despite association of the factor V G1691A (factor V Leiden) and prothrombin (factor II) G20210A mutations with venous thromboembolism and myocardial infarction [ 10 11 ] , neither mutation is strongly associated with risk of stroke [ 12 13 14 15 16 17 18 ] . Although a study of British adults found elevated levels of serum homocysteine to be associated with an increased risk of stroke [ 19 ] , a case-control study of a common polymorphism (methylenetetrahydrofolate reductase [MTHFR] T677C) that results in increased serum homocysteine concentrations found no difference between patients with stroke and controls in either genotype or allele frequency [ 20 ] . Because antiplatelet agents with different mechanisms of action can bring about significant reductions in stroke risk, several platelet receptor genes have been tested as candidate stroke susceptibility genes [ 21 22 ] . To date, however, no compelling evidence for an association between any platelet receptor gene polymorphism and risk of stroke has been found.
The breakdown of SAH, which is reversible, results in the release of free homocysteine which is converted to methionine while being used as a substrate for the reduction of 5-methylenetetrahydrofolate (5-MTHF) to tetrahydrofolate (THF).
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