Example sentences for: membrane-proximal

How can you use “membrane-proximal” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Shortly thereafter, the model gained direct and strong experimental support from a structural analysis in which the membrane-proximal helices of the two subunits were found to clasp in a weak “handshake” that could be disrupted by talin or constitutively activating mutations (Vinogradova et al.

  • Although we know that the membrane-proximal clasp on the integrin cytoplasmic face controls the integrin activation, the distal side of either the α or β cytoplasmic tails may also play a role in integrin activation, since other mutations indicate that the C-terminal membrane distal region is important in regulating integrin activation via a mechanism that is yet unknown.

  • Sarcospan is homologous to the tetraspanin superfamily, members of which have been shown to facilitate both integral-membrane and membrane-proximal protein interactions involved in many different cellular processes [ 12].

  • Since the membrane-proximal regions of integrin α and β cytoplasmic tails are highly conserved, the generalization of this signaling mechanism to all integrins was to be anticipated.


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