Example sentences for: lysophosphatidic

How can you use “lysophosphatidic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In this report, we questioned whether the EGFR acts as a surrogate scaffold during ERK activation through the δ-OR, as it appears to do for several other GPCRs [ 7 ] . To act as a surrogate-binding site for complex formation, the literature states that this protein must first become tyrosine-phosphorylated [ 7 ] . Tyrosine phosphorylation of the EGFR is apparent after agonist stimulation of the α 2 -AR (COS-7), β 2 -AR (COS-7), insulin-like growth factor (IGF-1; COS-7), substance P, and the lysophosphatidic acid receptor (LPAR) [ 7 ] . In addition, each of the aforementioned ligands also increases ERK phosphorylation when the proper receptor is expressed in these cell lines.

  • For a number of GPCRs, including the lysophosphatidic acid (LPAR) [ 7 ] , β-adrenergic 2 (β 2 -AR) [ 8 ] and μ- and δ-OR receptors [ 9 ] , the activation of a non-receptor tyrosine kinase of the Src or focal adhesion kinase (FAK) [ 10 ] families are involved.

  • PA can be further metabolized to diacylglycerol (DAG) and lysophosphatidic acid by PA phosphohydrolase and phospholipase A 2 , respectively.

  • DAG is an activator of certain isozymes of PKC and lysophosphatidic acid acts as an intercellular messenger for many cell types.


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