Words similar to locally
Example sentences for: locally
How can you use “locally” in a sentence? Here are some example sentences to help you improve your vocabulary:
Many souvenir shops in the major resorts tend to cater to the popular; however, you don’t need to look far to find locally produced goods that make wonderful remembrances of your trip and the narrow streets of the old towns are the perfect places to browse for hours.
A short walk away is the cathedral, known locally as La Manquita — the one-armed lady — because one of its twin towers remains unfinished.
During her career, she accomplished several things to improve legal funding for the poor, locally and nationwide.
In some circumstances, CD4 +and CD8 +T cells were rendered inactive in tumor-bearing hosts [ 8 ] . The inactivation of CD4 +T cells has been attributed either to the tumor cells themselves or to bone marrow-derived cells [ 9 10 11 ] , whereas antigen ignorance or loss of memory have been postulated to underlay that of CD8 +T cells [ 12 13 ] . Other studies have suggested that tumor cells can secrete immunosuppressive factors such as TGF-β or express Fas ligand to induce apoptosis of infiltrating lymphocytes [ 14 15 16 ] . Furthermore, the tumor vasculature appears to be quite different from normal blood vessels, in terms of structural organization, interstitial pressure, and flow patterns [ 17 ] , and in reduced lymphocyte and natural killer cell homing and adhesion [ 18 19 20 21 ] . The existence of significant barriers to effective immunological destruction is further illustrated by a mouse model of concurrent multistage tumorigenesis and anti-oncogene autoimmunity, wherein progenitor dysplastic lesions are infiltrated and disrupted, while solid tumors are not [ 22 ] . The hypothesis is that the microenvironment of certain types of solid tumor can serve to locally suppress T cell infiltration.
Although VEGF is produced locally in both of these circumstances, it is not known whether systemic administration of the factor could exacerbate these conditions by further stimulating vessel growth.
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