Words similar to localized
Example sentences for: localized
How can you use “localized” in a sentence? Here are some example sentences to help you improve your vocabulary:
Boi1 and Boi2 are localized to sites of polarized growth, consistent with the view that they are involved in polarized growth.
p27 is a cyclin-dependent kinase (cdk) inhibitor, and is normally expected to be localized to the cell nucleus.
Based on this arrangement and the sequence of the adjacent neck domain, we assigned KIF27 to the N-5 phyogenetic group of kinesins [ 27 ] . The N-5 subgroup is defined by the human KIF4 protein, which is primarily localized to the nuclear matrix and associates with chromosomes during mitosis [ 35 ] . In cell division, nuclear kinesins of this chromokinesin class appear to be important for the maintenance of sister chromatids on the metaphase plate [ 36 ] . However, additional functions for nuclear kinesins have recently been uncovered.
Reiterated sequence elements are often observed to form an unwound S1 nuclease-sensitive DNA conformation, termed anisomorphic or left-handed DNA, when present in negatively supercoiled plasmids [ 22 24 ] . Nuclease-sensitive secondary structures within the HSV origin of replication are believed to be recognized by the viral origin binding protein, and mutations that reduce this complex formation in vitro also reduce viral replication, thereby indicating that localized torsional strain may occur during viral DNA replication [ 1 ] . The
In response to receptor activation, Syk becomes non-covalently associated with the BCR through tandem SH2 domains located in the amino terminal half of the protein [ 44 ] . Following engagement of the BCR, phosphorylation of specific tyrosine residues in immunoreceptor tyrosine-based activation motifs (ITAMs) found within the cytoplasmic tails of CD79a and CD79b provides docking sites for Syk localization [ 45 46 47 ] . The ability of phosphorylated ITAM peptides to selectively enhance Syk kinase activity in vitro suggests that recruitment of Syk to the receptor complex may serve to activate the kinase, in part, through allosteric changes in the structure of the Syk protein [ 44 48 49 ] . Upon activation, Syk and the receptor complex become localized in detergent-resistant cholesterol-rich membrane microdomains (lipid rafts), resulting in the segregation of the BCR complex from other membrane components [ 50 ] .
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