Words similar to ionotropic
Example sentences for: ionotropic
How can you use “ionotropic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Two types of ionotropic glutamate receptors have been classified: (1) NMDA receptors, which bind glutamate and the glutamate analogue N-methyl-D-aspartate (NMDA); (2) non-NMDA receptors, which are stimulated by kainate, AA-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and quisqualate, but not NMDA.
The ionotropic AMPA glutamate receptor GluR4 subunit has been shown to be expressed by activated rat adult microglia
The group I mGluRs typically are located postsynaptically (as well as in other compartments of the cell) [ 16 17 18 ] where they regulate activity of ionotropic receptors and are necessary in some forms of synaptic plasticity [ 19 ] . The association of mGluRs with scaffolding proteins such as Homer (group I; [ 20 ] ) and PICK-1 (group III; [ 21 ] ) is important in regulating mGluR localization and function [ 21 22 23 24 ] . In addition to those proteins involved in scaffolding, other proteins have been shown to associate with mGluRs.
The possibility that domoic acid may activate neonatal microglia both in vitro and in vivo is suggested by recent observations with kainic acid, a domoic acid and glutamate analog that can induce upregulation of neonatal microglia scavenger receptor mRNA [ 22 ] and tissue plasminogen activator release [ 23 ] . The putative molecular explanation for these observations has been that kainic acid activates the ionotropic AMPA glutamate GluR4 subunit which has recently been shown to be expressed by activated microglia following transient forebrain ischemia in vivo [ 24 ] . Because this subunit of the AMPA glutamate receptor has affinity for domoic acid [ 25 26 27 ] , we hypothesized that domoic acid might activate neonatal microglia in vitro and lead to concomitant mediator release [ 21 ] .
Thus, in a recent report ionotropic AMPA glutamate receptors were shown to " ...function not only as ion channels but also as cell-surface transducers by means of their interaction with the Src-family non-receptor protein kinase Lyn.
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