Words similar to ionotropic
Example sentences for: ionotropic
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The ionotropic AMPA glutamate receptor GluR4 subunit has been shown to be expressed by activated rat adult microglia
The possibility that domoic acid may activate neonatal microglia both in vitro and in vivo is suggested by recent observations with kainic acid, a domoic acid and glutamate analog that can induce upregulation of neonatal microglia scavenger receptor mRNA [ 22 ] and tissue plasminogen activator release [ 23 ] . The putative molecular explanation for these observations has been that kainic acid activates the ionotropic AMPA glutamate GluR4 subunit which has recently been shown to be expressed by activated microglia following transient forebrain ischemia in vivo [ 24 ] . Because this subunit of the AMPA glutamate receptor has affinity for domoic acid [ 25 26 27 ] , we hypothesized that domoic acid might activate neonatal microglia in vitro and lead to concomitant mediator release [ 21 ] .
Increases in the amount of protein for ionotropic receptor subunits were observed in the membrane fraction isolated from retinae of the rdta mice.
Thus, in a recent report ionotropic AMPA glutamate receptors were shown to " ...function not only as ion channels but also as cell-surface transducers by means of their interaction with the Src-family non-receptor protein kinase Lyn.
This fact is reflected in the analysis of literature profiles, as groups of genes could be found to be associated with brain tissues (Figure 7f, for example, HPCA (hippocalcin), SYP (synaptophysin), GRIK1 (glutamate receptor, ionotropic, kainate 1), APLP (amyloid beta A4 precursor-like protein)), immune cells (Figure 7b, for example, CD40, IL15RA (IL-15 receptor, alpha chain), LILB4 (leukocyte immunoglobulin-like receptor 4)) or tumor cells (Figure 7a, for example, MYBL1 (v- myb avian myeloblastosis viral oncogene), ABL2 (v- abl Abelson murine leukemia viral oncogene homolog 2)).
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