Example sentences for: ionotropic

How can you use “ionotropic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Thus, in a recent report ionotropic AMPA glutamate receptors were shown to " ...function not only as ion channels but also as cell-surface transducers by means of their interaction with the Src-family non-receptor protein kinase Lyn.

  • One of these is Grk2 , a member of the family of ionotropic glutamate receptor genes that is thought to play a role in modulating Huntington disease [ 44].

  • The ionotropic AMPA glutamate receptor GluR4 subunit has been shown to be expressed by activated rat adult microglia

  • The possibility that domoic acid may activate neonatal microglia both in vitro and in vivo is suggested by recent observations with kainic acid, a domoic acid and glutamate analog that can induce upregulation of neonatal microglia scavenger receptor mRNA [ 22 ] and tissue plasminogen activator release [ 23 ] . The putative molecular explanation for these observations has been that kainic acid activates the ionotropic AMPA glutamate GluR4 subunit which has recently been shown to be expressed by activated microglia following transient forebrain ischemia in vivo [ 24 ] . Because this subunit of the AMPA glutamate receptor has affinity for domoic acid [ 25 26 27 ] , we hypothesized that domoic acid might activate neonatal microglia in vitro and lead to concomitant mediator release [ 21 ] .

  • Figure 6Ashows the effect of the ionotropic glutamate receptor antagonist, kynurenic acid (Kyn-A, 7 mM), on γ oscillations.


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