Example sentences for: ionophore

How can you use “ionophore” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Arguing for the specificity of this effect is the stimulation of LH secretion by a calcium ionophore and the failure of LH stores and GnRH-receptor binding to be affected by RGS3.

  • 2 S505A translocates in CHO cells in response to ionophore, we were able to directly compare rates of translocation between cPLA 2 and cPLA 2 S505A to a physiological agonist and found no difference between translocation rates or intracellular targeting.

  • Phosphorylation of cPLA 2 on Ser 505has been hypothesized to play a role in Ca 2+-mediated translocation since Ser 505phosphorylation is required for cPLA 2 -mediated AA release in response to low-dose, but not high-dose, ionophore [ 22 ] . Translocation of cPLA 2 S505A in CHO cells has been reported in response to ionophore stimulation [ 25 ] , but the effect of Ser 505phosphorylation on the kinetics of translocation, targeting, and in response to a physiological agonist was not investigated.

  • For example, cPLA 2 constructs with a S505A mutation have long been recognized as unable to support AA release in response to physiological agonists or low-dose ionophore when transfected in cells.

  • Confluent HUVEC were washed with HBSS and incubated for 30 min at 37°C with various agonists in HBSS with 0.35%BSA: HBSS alone; 0.5 % dimethyl sulfoxide (DMSO); ionophore A23187 1-100 μmol/L; phorbol myristate acetate (PMA) 1 μg/mL; human thrombin receptor activating peptide SFLLRNP (TRAP) 1-50 μmol/L; human thrombin (THR) US FDA standard lot J (Bethesda, MD) 0.1-10 NIH Unit/mL; human tissue plasminogen activator (TPA) 3.5 kU/mL or human angiotensin II (AGTII) 1 μmol/L.


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