Words similar to ionophore
Example sentences for: ionophore
How can you use “ionophore” in a sentence? Here are some example sentences to help you improve your vocabulary:
Calcium is an established stimulator of LH secretion that is thought to act at sites downstream of phospholipase C [ 39 40 ] . Therefore, adeno-RGS3 infected pituitary cells were treated with a calcium ionophore (A23187).
Flow cytometry analysis of HUVEC culture supernatant demonstrated that a 30 min treatment with 10 μM ionophore A23187 caused the release of low counts of annexin V-binding MP (Fig.
In vitro studies have demonstrated that dephosphorylated cPLA 2 is catalytically active and that Ser 505phosphorylation increases activity by only ~30 percent [ 24 ] . In contrast, cells expressing the cPLA 2 S505A mutation fail to release AA in response to a low dose of calcium ionophore, but release similar amounts of AA as cells expressing wild-type cPLA 2 in response to high dose ionophore [ 22 ] . From these studies, it has been suggested that cPLA 2 Ser 505phosphorylation may have a role in regulating translocation [ 22 ] . A previous study demonstrated translocation of cPLA 2 S505A in response to Ca 2+ionophore, but did not address the kinetics of translocation, translocation in response to a physiological agonist, or differences in targeting [ 25 ] .
[ 35 ] . Most studies of cPLA 2 translocation have utilized ionophore, which elicits a large, supraphysiological sustained increase in [Ca 2+] i [ 14 15 25 35 36 37 38 ] , or agonists that produce a sustained [Ca 2+] i increase [ 35 ] . Under these conditions, a large proportion of cPLA 2 binds to membrane.
Pituitary cells that had been re-trypsinized 72 h after infection and then replated (100,000 cells/well in a 24-well poly-L-lysine coated plate) for a 2 h preincubation were subsequently treated with a GnRH agonist (1 ml of 10 -7M D-Ala 6- des Gly 10- GnRH ethylamide; GnRH-A, Sigma, St. Louis, MO) or a calcium ionophore (A23187, Sigma) for 3 h as described by Conn et al.
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