Words similar to ionophore
Example sentences for: ionophore
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In vitro studies have demonstrated that dephosphorylated cPLA 2 is catalytically active and that Ser 505phosphorylation increases activity by only ~30 percent [ 24 ] . In contrast, cells expressing the cPLA 2 S505A mutation fail to release AA in response to a low dose of calcium ionophore, but release similar amounts of AA as cells expressing wild-type cPLA 2 in response to high dose ionophore [ 22 ] . From these studies, it has been suggested that cPLA 2 Ser 505phosphorylation may have a role in regulating translocation [ 22 ] . A previous study demonstrated translocation of cPLA 2 S505A in response to Ca 2+ionophore, but did not address the kinetics of translocation, translocation in response to a physiological agonist, or differences in targeting [ 25 ] .
In this experiment, a direct destabilizing effect of the Ca 2+-ionophore A23187 on cell membrane resulting in MP formation is also likely.
2 S505A translocates in CHO cells in response to ionophore, we were able to directly compare rates of translocation between cPLA 2 and cPLA 2 S505A to a physiological agonist and found no difference between translocation rates or intracellular targeting.
Phosphorylation of cPLA 2 on Ser 505has been hypothesized to play a role in Ca 2+-mediated translocation since Ser 505phosphorylation is required for cPLA 2 -mediated AA release in response to low-dose, but not high-dose, ionophore [ 22 ] . Translocation of cPLA 2 S505A in CHO cells has been reported in response to ionophore stimulation [ 25 ] , but the effect of Ser 505phosphorylation on the kinetics of translocation, targeting, and in response to a physiological agonist was not investigated.
Flow cytometry analysis of HUVEC culture supernatant demonstrated that a 30 min treatment with 10 μM ionophore A23187 caused the release of low counts of annexin V-binding MP (Fig.
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