Example sentences for: interactions

How can you use “interactions” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These potential isoforms may have altered biological function due to the loss of domain specific interactions.

  • For example, using methods discussed by Goodman [ 42 ] , the power to detect interactions for multiple scenarios is possible.

  • The open channel noise of multiple channel currents is smaller than single channel currents, adding to the collection of properties altered by interactions (Figure 3D).

  • These dynamics are regulated both by a variety of protein-protein and protein-DNA interactions and by catalytic modification and reorganization of proteins and nucleic acids that comprise the chromosomes [ 3].

  • AtCOP1 contains three conserved structural domains: a RING finger at the amino terminus, a coiled-coil domain in the middle, and a carboxyl-terminal WD40 repeat domain [ 9 10 ] . Each of the three conserved domains has been shown to mediate protein-protein interactions [ 11 12 13 ] . The subcellular localization of AtCOP1 is regulated by light in a tissue specific manner [ 14 15 ] . The hypocotyl cell nuclei contain high levels of COP1 in the dark and reduced levels in the light, suggesting that the nucleocytoplasmic partitioning of AtCOP1 is adjusted by a light-responsive mechanism [ 14 16 ] . The activity of AtCOP1 is at least in part regulated by its subcellular localization, as the degradation of HY5 is dependent upon the nuclear accumulation of AtCOP1 in the dark [ 4 ] . AtCOP1 was demonstrated to carry a single, bipartite nuclear localization signal located between the coiled-coil domain and the WD-40 domain (amino acid 294-314) and a cytoplasmic localization signal, which was mapped to a region partially overlapping with the RING finger and the coiled-coil domain (amino acid 67-117) [ 17 ] . Strikingly, AtCOP1 protein forms characteristic nuclear speckles when transiently expressed in onion epidermal cells or stably expressed in transgenic Arabidopsis [ 6 18 ] . The functional role of these speckles is currently unknown; however, a subnuclear localization signal consisting of 58 residues (amino acid 120-177) is required for their formation [ 19 ] .


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