Words similar to interacts
Example sentences for: interacts
How can you use “interacts” in a sentence? Here are some example sentences to help you improve your vocabulary:
In the NetSearch-generated model, Bck1p is downstream of Mkk1p because, although it interacts with both Mkk1p and Mkk2p, it has been shown specifically not to interact with Pkc1p in two-hybrid assays [ 18 ] .
We then used the 5' and 3' fusions of the Cas SD to determine which motif, YQXP or YDXP, interacts with the v-crk SH2 domain.
[ 20 ] ]. High-risk HPV E6 and E7 gene expression can independently immortalize various human cell types in vitro . The E6 gene interacts with p53 and an apoptotic protein BAK , followed by its degradation, which results in chromosomal instability and resistance to apoptosis [ 21 22 ] . The E7 protein interacts with pRB followed by its degradation [ 23 ] . The p53 and pRB proteins have been shown to play multiple roles in cell growth and in genomic integrity.
The protein product of the mdm2 oncogene is over-expressed in a considerable number of tumors [ 27 ] . This protein is a pivotal negative regulator of p53 [ 27 ] ; it interacts with the P53 protein masking its transcriptional domain and accelerating its proteasomal degradation [ 21 27 ] . The later process involves the deacetylation and ubiquitylation of the p53 protein by mdm2 [ 28 ] . Inactivation and/or degradation of p53 diminishes the cell ability to undergo apoptosis [ 21 ] . Conversely, p53 may influence mdm2.
Investigators have shown that v-crk interacts via its SH2 domain with the substrate domain of Cas [ 6 ] . Association of v-crk with endogenous Cas is believed to protect the phosphorylation status of this molecule due to protection from phosphatases [ 12 ] . Expression of an unphosphorylated Cas SD along with v-crk should therefore result in stable tyrosine phosphorylation of the Cas SD if they interact.
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