Words similar to interacting
Example sentences for: interacting
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This approach had been pioneered in the classical work of Dobzhansky and Sturtevant who used inversions in Drosophila chromosomes to construct an evolutionary tree [ 12 ] . Subsequently, mathematical methods have been developed to calculate rearrangement distances between genomes, and, using these, phylogenetic trees have been built for certain small genomes, such as plant mitochondria and herpesviruses [ 13 14 ] . These approaches, however, are applicable only to genomes that show significant conservation of global gene order, which is manifestly not the case among prokaryotes [ 15 16 17 ] . Even relatively close species such as, for example, Escherichia coli and Haemophilus influenzae, two species of the γ-subdivision of Proteobacteria, retain very little conservation of gene order beyond the operon level (typically, two-to-four genes in a row), and essentially none is detectable among evolutionarily distant bacteria and archaea [ 15 16 18 ] . Very few operons, primarily those coding for physically interacting subunits of multiprotein complexes such as certain ribosomal proteins or RNA-polymerase subunits, are conserved across a wide range of prokaryotic lineages [ 15 16 ] . On the other hand, pairwise comparisons of even distantly related prokaryotic genomes reveal considerable number of shared (predicted) operons, which creates an opportunity for a meaningful comparative analysis [ 19 ] [ 20 21 ] .
In addition to Y140 and W89, d -tc has also been observed to interact with D206 and several other residues in loop C [ 27 ] . The d -tc binding site appears to involve interaction with at least three different binding loops (A, E and C) although additional interacting amino acids may be found.
A small protein Ump1 associates with the premature proteasome complexes and is shown to be involved in assisting the maturation of 20S proteasome, possibly by interacting with the β rings of half proteasomes [ 46 ] . Upon the maturation of the 20S proteasome, Ump1 is trapped inside the proteasome and is degraded by proteasome [ 46 ] . The HSP70 like chaperon protein Hsc73 also associates with the 16S proteasome precursor complexes [ 35 36 ] . The exact role of Hsc73 in 16S precursor proteasome complex is not known, but has been suggested to assist proteasome maturation [ 35 36 ] . Our studies add Smad1, Smad1 interacting proteins such as SNIP1, Smad4, and Az as additional proteins that associate with the assembly intermediates.
The lack of a large change in K i for both analogs makes it difficult to interpret this data since one or both of the compounds appears to be interacting differently with the binding site than lerisetron.
1) emerge from the interconnections of simple pathways under local control [ 15 16 17 ] . As such, these cellular pathways are more analogous to the mostly redundant, overlapping neural network of the brain than to traffic grids of intersecting streets and interacting vehicles.
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