Words similar to interacting
Example sentences for: interacting
How can you use “interacting” in a sentence? Here are some example sentences to help you improve your vocabulary:
The DLG5 gene encodes for a protein that is a member of the MAGUK (Membrane Associated Guan late Kinase homologs) family of proteins located in the plasma membrane [ 2 ] . MAGUK is a new family of proteins that act as a molecular scaffold for intracellular signaling pathways [ 11 ] . The MAGUK family of proteins is characterized by domains that interact with other proteins to create an assembly of large multi-protein complexes [ 10 ] . The PDZ (PSD-95, DLG and ZO-1) domains are the best characterized for their binding to the C-terminal region of channels and transmembrane proteins [ 11 ] . Usually each protein has 1-3 copies of such domains [ 8 12 13 ] . The SH3 domain (Src homology 3) are present in proteins that couple transmembrane receptors to signaling molecules [ 14 ] . The presence of this domain in MAGUKs increases their possibilities of interacting with signaling pathways.
Other known NR corepressors include RIP140 [ 10 ] , Hairless [ 11 ] , short heterodimer partner (SHP) [ 12 ] and DAX [ 13 ] , and receptor specific corepressors such as the estrogen receptor (ER) interacting proteins REA and HET-SAFB [ 14 15 ] .
To investigate ERβ interactions with corepressors, we examined the interactions of full length ERβ (amino acids 1-530) with bacterially expressed C-terminal NR interacting domain of N-CoR (amino acids 1944-2453) in vitro (Fig.
Even though our methods produced mediocre results at CASP1, we realised that a major problem with accurate comparative modelling had to do with the interconnected nature of protein structures [ 23 ] : If a certain region of the protein varied with respect to the homologue, then it was likely that a structurally interacting region would also vary, even if that region was conserved in sequence.
However, when the structure was redrawn based on comparative analysis (Figure 2b) [ 13 ] , and the new helix containing the κ interacting element was deleted (nts 185-201), the frequency dropped over 1000-fold.
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