Example sentences for: immunoglobulin

How can you use “immunoglobulin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • One representative pedigree demonstrating these disparities between immunoglobulin phenotype, frequency of infections, and HLA haplotype is displayed in Figure 1. In a second kinship, two different haplotypes segregated with antibody deficiency, although the immunoglobulin deficiency pattern was different in each of three affected family members (Fig.

  • Common variable immunodeficiency (CVID) and selective immunoglobulin G subclass deficiency (IgGSD) are characterized by subnormal serum concentrations of total IgG, or by normal serum total IgG concentrations with deficiency of one or more IgG subclasses, respectively; in some cases, IgA or IgM levels are also subnormal [ 1 2 3 ] . Most persons are diagnosed to have CVID or IgGSD because they have increased frequency and severity of infections due to bacteria and other microbial pathogens [ 1 4 ] . Although a susceptibility locus for these disorders has not been identified, they often appear to be familial and to segregate with markers on Ch6p [ 1 5 6 ] .

  • Because B-cell activation and differentiation result in dramatic increases in immunoglobulin V gene messenger RNA, these fingerprinting assays cannot readily distinguish between clonal expansion and activation when cDNA is used as a starting template.

  • We thus devised an experiment where we constructed models for protein families with large numbers of known structures (specifically the globin and the immunoglobulin families).

  • The importance of the Tec kinases in antigen receptor signaling was first demonstrated by the observation that mutations in BTK result in the human disease X-linked agammaglobulinemia (XLA) and the murine counterpart X-linked immunodeficiency ( xid ). These severe B cell immunodeficiencies are characterized by diminished numbers of mature B cells and reduced immunoglobulin levels associated with impaired PLC-γ activation and Ca ++mobilization in response to surface IgM stimulation (sIgM) [ 8, 9, 10, 11].


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