Words similar to immunogens
Example sentences for: immunogens
How can you use “immunogens” in a sentence? Here are some example sentences to help you improve your vocabulary:
In animal models of HIV, different immunogens and modes of immunization can induce different modes of protection with varying degrees of effectiveness [ 34 35 36 37 38 39 40 ] Harnessing multiple immune responses may be the answer to designing an effective HIV vaccine [ 1 ] and the availability of multiple vectors may facilitate the harnessing of multiple responses.
Much work obviously remains to be done to develop dengue replicons as effective vectors for HIV immunogens.
More work needs to be done on determining the ability of dengue replicons to express other potential immunogens, including HIV-1 gag, tat (reviewed in 41) and env genes with deleted hypervariable regions [see [ 42 ] ]. Animal studies in our lab are currently being initiated to determine the nature of the immune response such vectors can induce in mice and these studies will presumably need to be extended to primates.
As a live, attenuated vaccine for HIV is considered difficult to test and dangerous to implement [ 1 2 5 6 7 8 9 ] , various alternatives to HIV could be considered as potential "live" vectors for HIV immunogens, including enteric bacteria, poxviruses (vaccinia and canarypox), small RNA viruses (e.g.
Antigen-specific T cells encounter antigen presented by dendritic cells that migrate to the paracortical regions of draining lymph nodes after initial antigen contact [ 1 ] . Only dendritic cells have the capacity to induce activation in resting peripheral T cells [ 2 3 ] . Once activated, differentiated T helper cells contact antigen-specific B cells and provide signals for B cell differentiation via CD154-CD40 interactions, as well as by the production of cytokines [ 4 5 6 ] . Consistent with this general understanding of the induction of antibody responses to protein immunogens, good antibody responses to synthetic peptide-epitope constructs have been shown to depend on the presence, orientation, and multiplicity of the T cell epitope in the construct [ 7 8 9 10 11 ] . As a confirmation of this finding with synthetic epitope constructs, most protein immunogens studied to date contain multiple T cell epitopes, for example [ 12 13 ] .
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